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1.
Anna Kakehashi Akihiro Hagiwara Norio Imai Min Wei Shoji Fukushima Hideki Wanibuchi 《Journal of toxicologic pathology》2015,28(1):27-32
In the present study, in continuation of our previous experiment in order to investigate the mode of action (MOA) of ethyl tertiary-butyl ether (ETBE) hepatotumorigenicity in rats, we aimed to examine alterations in cell proliferation, that are induced by short-term administration of ETBE. F344 rats were administered ETBE at doses of 0, and 1,000 mg/kg body weight twice a day by gavage for 3, 10, 17 and 28 days. It was found that the previously observed significant increase of P450 total content and hydroxyl radical levels after 7 days of ETBE administration, and 8-OHdG formation at day 14, accompanied by accumulation of CYP2B1/2B2, CYP3A1/3A2, CYP2C6, CYP2E1 and CYP1A1 and downregulation of DNA oxoguanine glycosylase 1, was preceded by induction of cell proliferation at day 3. Furthermore, we observed an increase in regenerative cell proliferation as a result of ETBE treatment at day 28, followed by induction of cell cycle arrest and apoptosis by day 14. These results indicated that short-term administration of ETBE led to a significant early increase in cell proliferation activity associated with induction of oxidative stress, and to a regenerative cell proliferation as an adaptive response, which could contribute to the hepatotumorigenicity of ETBE in rats. 相似文献
2.
Ayano OMURA Wataru ANZAI Daisuke KOYABU Hideki ENDO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(9):1043-1048
Clarification of the trunk structure in Urodela is important in understanding the
locomotive evolution of basal tetrapods. The components of the muscular trunk wall among
Urodela using different modes of locomotion were compared. Since the whole trunk may be
used for swimming and the effect of limbs may be small in the more aquatic species, they
showed smaller differences in the trunk muscles among anterior, middle and posterior
sections of the trunk. By contrast, in the more terrestrial species, the dorsal and
abdominal muscles are larger in the middle section than those in the anterior and
posterior sections. High compressive stresses occur in the supporting limbs and their
insertion at the trunk on the ventral side, and spread from the forelimbs along the back
to the supporting hindlimbs on the dorsal side. Tensile stresses occur in the middle
ventral part. The components of the trunk muscles among the three sections may reflect
differences in stresses occurring in the trunk of the more terrestrial species. The
findings also suggest that in the middle section, larger dorsal muscles for stiffening the
back to maintain posture and larger abdominal muscles are responsible for balancing the
body weight while it is supported by the limbs in the more terrestrial species. 相似文献
3.
Kent MORI Satoshi SUZUKI Daisuke KOYABU Junpei KIMURA Sung-Yong HAN Hideki ENDO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(5):571-578
Although the sea otter (Enhydra lutris) is a complete aquatic species,
spending its entire life in the ocean, it has been considered morphologically to be a
semi-aquatic animal. This study aimed to clarify the unique hindlimb morphology and
functional adaptations of E. lutris in comparison to other Mustelidae
species. We compared muscle mass and bone measurements of five Mustelidae species: the sea
otter, Eurasian river otter (Lutra lutra), American mink
(Neovison vison), Japanese weasel (Mustela itatsi) and
Siberian weasel (M. sibirica). In comparison with the other 4 species,
E. lutris possessed significantly larger gluteus, popliteus and
peroneus muscles, but smaller adductor and ischiopubic muscles. The popliteus muscle may
act as a medial rotator of the crus, and the peroneus muscle may act as an abductor of the
fifth toe and/or the pronator of the foot. The bundles of the gluteus superficialis muscle
of E. lutris were fused with those of the tensor fasciae latae muscle and
gluteofemoralis muscles, and they may play a role in femur abduction. These results
suggest that E. lutris uses the abducted femur, medially rotated crus,
eversion of the ankle and abducted fifth digit or extended interdigital web as a powerful
propulsion generator. Therefore, we conclude that E. lutris is a complete
aquatic animal, possessing differences in the proportions of the hindlimb muscles compared
with those in other semi-aquatic and terrestrial mustelids. 相似文献
4.
Tetsuji Ota Tsuyoshi Kajisa Nobuya Mizoue Shigejiro Yoshida Gen Takao Yasumasa Hirata Naoyuki Furuya Takio Sano Raul Ponce-Hernandez Oumer S. Ahmed Heng Sokh Vuthy Ma Eriko Ito Jumpei Toriyama Yukako Monda Hideki Saito Yoshiyuki Kiyono Sophal Chann Nang Ket 《Journal of Forest Research》2015,20(6):484-492
5.
Ayano OMURA Hideki ENDO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2016,78(1):43-47
The digestive organs in decapodiform cephalopod species morphologically vary by
individual lifestyle. We examined the following six species of adult decapodiformes
cephalopods representing different habitats: Todarodes pacificus, Loligo
bleekeri, Loligo edulis, Watasenia
scintillans (pelagic), Sepia lycidas and Euprymna
morsei (benthic). L. bleekeri and L. edulis
possess a bursiform cecal sac connected to the cecum. Pelagic species have a single
digestive gland smaller than in benthic species. T. pacificus has an oval
digestive gland larger than that of L. bleekeri and L.
edulis, which possess withered-looking and smaller digestive glands. In
contrast, the digestive glands in benthic species are paired. S. lycidas
and E. morsei have well-developed and larger digestive glands than those
of the pelagic species. Well-developed digestive duct appendages are found in benthic
species. In qualification of the mass of digestive organs, pelagic species have smaller
stomachs, digestive glands and digestive ducts’ appendages than benthic species. Because
pelagic species need to swim, they may possess smaller stomachs and larger cecums for more
rapid digestion. A smaller digestive gland may have the advantage of reducing the body
weight in pelagic species for rapid swimming. In contrast, since benthic species require a
longer time for digestion than pelagic species, they compact more food in their stomachs
and absorb nutrients via more organs, such as the digestive grand and digestive duct
appendages, in addition to cecum. 相似文献
6.
Masashi Fujinaga Naho Yamagishi Hideki Ogiso Jun Takeuchi Jouji Moriwaki Toyozo Sato 《Journal of General Plant Pathology》2011,77(4):243-247
A new disease was found in Japan, on celery (Apium graveolens var. dulce) having severe chlorotic leaf spot, stunt, and dwarf with leaf curl. A spore suspension from the fungus isolated from affected
plants induced identical symptoms 14 days after plants were sprayed. Identification and molecular characterization showed
that the causal agent is Colletotrichum simmondsii. This report is the first of stunt anthracnose on celery caused by C. simmondsii. We propose the name “stunt anthracnose” for the new disease. Colletotrichum acutatum sensu lato, as reference pathogen of celery anthracnose, should be changed to C. fioriniae based on morphological and molecular characteristics. 相似文献
7.
本文从林业和环境的可持续性的视点出发,对关系到森林的退耕还林政策的成果和问题以及最近开始的林权制度改革的内容和课题进行了实地考察和探讨,针对今后中国的森林和环境保护的方向进行了论述。 相似文献
8.
In a roasted Arabica coffee brew, the potent roasty odor quality compound was identified as 3-mercapto-3-methylbutyl acetate by comparison of its Kovats gas chromatography retention index, mass spectrum, and odor quality to those of the synthetic authentic compound. 3-Mercapto-3-methylbutyl acetate has been identified for the first time in the coffee, and according to the results of the aroma extract dilution analysis, the contribution of this compound to the flavor of the roasted coffee brew varied depending on the degree of the coffee bean roasting. The concentration of this compound in the coffee brews as with 3-mercapto-3-methylbutyl formate increased with an increase in the degree of roasting. However, the slope of the amount of both esters was different, and 3-mercapto-3-methylbutyl acetate hardly increased with a low degree of roasting at more than a 21 luminosity (L)-value, but it rapidly increased when the roasting degree of the coffee beans reached the L-value of 18. These results suggested that the contribution of 3-mercapto-3-methylbutyl acetate to the overall flavor is peculiar to the flavor of the highly roasted coffee. 相似文献
9.
The aim of this study was to clarify the formation mechanism of a potent off-odorant, p-methylacetophenone, from citral under acidic aqueous conditions. An acidic aqueous solution (pH 3.0) containing 10 mg/L of citral was stored at 40 degrees C for 2 weeks. Among the compounds detected in the stored citral solution, 4-(2-hydroxy-2-propyl)benzaldehyde was identified for the first time as a degradation product from citral. The formation of p-methylacetophenone and 4-(2-hydroxy-2-propyl)benzaldehyde behaved the same when antioxidants were added to the citral solution. In addition, both compounds were formed by the Fe(2+)-induced decomposition of 8-hydroperoxy-p-cymene, another compound identified in the stored citral solution. These results suggested that both p-methylacetophenone and 4-(2-hydroxy-2-propyl)benzaldehyde can be formed via the same radical intermediate [p-CH3C6H4C(CH3)2O*] that can be derived from the O-O bond homolysis of 8-hydroperoxy-p-cymene. On the other hand, the degradation of 8-hydroperoxy-p-cymene without Fe2+ under acidic aqueous conditions did not yield p-methylacetophenone and 4-(2-hydroxy-2-propyl)benzaldehyde, but the degradation of citral without Fe2+ did. Therefore, other than the decomposition of 8-hydroperoxy-p-cymene, a mechanism to generate the tert-alkoxy radical intermediate was proposed for the formation of p-methylacetophenone and 4-(2-hydroxy-2-propyl)benzaldehyde in the citral solution. 相似文献
10.
Tsuboi M Etoh H Kato K Nakatugawa H Kato H Maejima Y Matsumoto G Mori H Hosokawa M Miyashita K Tokuda H Suzuki N Maoka T 《Journal of agricultural and food chemistry》2011,59(19):10572-10578
The in vitro reactivity of capsanthin (1) and fucoxanthin (2) with peroxynitrite was investigated, and the reaction products produced by scavenging with peroxynitrite were analyzed. (14'Z)-Nitrocapsanthin (3) and 12-nitrocapsanthin (4) were isolated from the products of the reaction of capsanthin with peroxynitrite. Similarly, (14Z)-15-nitrofucoxanthin (5), (11Z)-11-nitrofucoxanthin (6), and (14Z,9'Z)-15-nitrofucoxanthin (7) were obtained from the reaction of peroxynitrite reaction with fucoxanthin. Capsanthin and fucoxanthin inhibited the nitration of tyrosine by peroxynitrite. Furthermore, nitrocapsanthins (3 and 4) and nitrofucoxanthins (5 and 6) exhibited an inhibitory effect on Epstein-Barr virus early antigen activation in Raji cells and an antiproliferative effect on human pancreatic carcinoma. Moreover, nitrocapsanthins (3 and 4) inhibited carcinogensis of mouse skin tumors initiated by 7,12-dimethylbenz[a]anthracene (DMBN). 相似文献