Fusarins G–L with Inhibition of NO in RAW264.7 from Marine-Derived Fungus Fusarium solani 7227

Six new fusarin derivatives, fusarins G–L (1–6), together with five known compounds (5–11) were isolated from the marine-derived fungus Fusarium solani 7227. The structures of the new compounds were elucidated by means of comprehensive spectroscopic methods (1D and 2D NMR, HRESIMS, ECD, and ORC) and X-ray crystallography. Compounds 5–11 exhibited potent anti-inflammatory activity by inhibiting the production of NO in RAW264.7 cells activated by lipopolysaccharide, with IC₅₀ values ranging from 3.6 to 32.2 μM. The structure–activity relationships of the fusarins are discussed herein.     

Advanced Agriculture of lsrael Roots in its Decision Making Mechanism

ln the past 70 years, lsrael has not only realized the self-sufficiency of agri-cultural products, but also make its way to becoming one of leading exporters of agri-cultural products in the world rapi...     

月桂酸单甘油酯对花鲈脂质代谢的影响

为评价月桂酸单甘油酯(Glycerolmonolaurate,GML)对花鲈(Lateolabrax maculatus)脂质代谢的影响,文章通过基础饲料拌喂0 mg·kg?1(对照组)、1000 mg·kg?1(低剂量组)、2000 mg·kg?1(中剂量组)和4000 mg·kg?1(高剂量组)的GML,养殖均质量...     

Effect of 1α, 25-dihydroxyvitamin D3 on T helper cell 17 and expression of related cytokines in penetrating keratoplasty in mice

AIM: To evaluate the effects of 1α, 25-dihydroxyvitamin D3 on T helper cell 17 (Th17 cells) and its related cytokines in a mouse model of corneal allograft transplantation. METHODS: C57BL/6 mice were transplanted with corneal grafts from BALB/c mice and treated intraperitoneally with 1.0 μg 1α, 25-dihydroxyvitamin D3 or soybean oil every other day after operation. The transparency of the corneal grafts was evaluated for potential rejection signs by slit lamp biomicroscopy and histopathology. The expression levels of IL-17, RORγt and IFN-γ in the spleen were measured by real-time PCR. Moreover, the protein expression of RORγt and IL-17 in the peripheral blood was analyzed by Western blotting. IL-17 and IFN-γ in peripheral blood were measured by flow cytometry. RESULTS: 1α, 25-dihydroxyvitamin D3 significantly inhibited the rejection of the corneal allograft and reduced the numbers of inflammatory infiltrates in the corneal graft. In the spleen, 1α, 25-dihydroxyvitamin D3 treatment reduced the expression levels of IL-17, RORγt and IFN-γ. In the peripheral blood, 1α, 25-dihydroxyvitamin D3 treatment downregulated the expression levels of RORγt, IL-17 and IFN-γ. CONCLUSION: The effects of 1α, 25-dihydroxyvitamin D3 on suppressing corneal transplantation-induced allograft rejection in mice are closely associated with its modulation on IL-17 and related cytokine RORγt.     

饲养方式和卢氏绿壳蛋鸡经济效益的相关性

讨论不同饲养方式对卢氏绿壳蛋鸡体重、屠宰性能、消化器官、肠道组织的影响。本试验选取卢氏绿壳蛋鸡200只,其中放养组和笼养组各100只,且每组公鸡、母鸡各50只,对其相关指标进行测定分析。结果表明:放养鸡的各项指标都优于笼养鸡,产出效益较高,同时放养鸡具有较强的自由觅食能力,能起到降低成本的效果。通过经济性比较,养殖企业选择科学的管理方式有助于提高经济效益,增强市场竞争力,促进企业生存和发展。     

广东省首例非洲猪瘟疫情的诊断与疫点消毒效果评价

2018年12月17日,广东省珠海市某定点屠宰场发生该省首起非洲猪瘟疫情。诊断中发现,因病程不同,感染猪的临床症状和病理变化存在一定的差异,并非全部表现典型症状。疫情发生后,珠海市防控非洲猪瘟等动物疫病应急指挥部立即严格遵照《广东省非洲猪瘟突发疫情应急处置预案》的规定,采取了扑杀、消毒、发布封锁令,划定疫点、疫区和受威胁区等处置措施;封锁期内,按照《非洲猪瘟防治技术规范(试行)》规定,并参考联合国粮食及农业组织(FAO)技术标准,对疫点进行消毒,同时采集疫点内的环境样品,检测非洲猪瘟病毒(ASFV)核酸,评估消毒效果,为解除封锁提供依据。本文为全国非洲猪瘟疫情排查、临床诊断和处置提供了参考。     

福建地方梨资源果实性状多样性分析及其数量分类研究

对保存的50份福建省地方梨资源的26个果实性状进行数据采集,分析果实性状的分布频率、变异系数和Shannon-Weaver指数,应用Q型和R型聚类分析法对种质和性状进行分类,并基于果实性状进行主成分分析。结果表明:(1)所收集种质的果实描述性状多样性丰富,以果点明显、果锈多、果面粗糙、果肉脆、风味酸甜、无涩味、果心小和成熟期为9月的种质居多,分别占92%、52%、54%、50%、50%、70%、54%和80%。(2)数量性状中维生素C含量变异系数(67.60%)最大,其次为可滴定酸含量(48.26%)、糖酸比(42.22%)和固酸比(41.14%)。(3)描述性状Shannon-Weaver指数范围0.324～1.660,其中颜色和形状较高,多样性最丰富,而数量性状Shannon-Weaver指数范围达1.698～2.074,表现出更丰富的多样性。(4)Q型聚类分析在欧式距离为14.71时将供试种质分为5个组,组内具有一定的特征,组间存在差异,但并未发现按地域聚类的趋势;R型聚类分析在相关系数1.236处将果实性状聚为5组,多数性状间表现两两相关,部分性状间逻辑相关性明显。(5)主成分分析发现前10个主成分反映86.545%的贡献率,各性状贡献率较为分散,性状变异具有多向性;第1主成分的正向增长有利于提高果实内在品质,而第2、4主成分的正向增长有利于提高果实外观品质,第3主成分负向增长有利于增大果实大小。     

珠海市城区林地管理与集体林权制度改革

介绍珠海市城区林地管理和收入情况,以及林业生态建设现状.阐述城区森林资源林权制度历史沿革和管理情况.分析城区集体林地不适宜进行集体林权制度改革的原因,包括城区农业人口已全部转为城镇居民;林地主要为生态公益林地;历次林改不彻底,林地纠纷多等,并提出了将其转变为国有林地经营和管理的途径.     

猪口蹄疫○型合成肽疫苗诱导的免疫抗体的监测

设3组猪群,首免和二免分别注射生理盐水1 mL、猪口蹄疫0型合成肽疫苗1 mL(说明书推荐免疫剂量)及猪口蹄疫0型合成肽疫苗3 mL(说明书推荐免疫剂量3倍量),二免28天后检测猪群的口蹄疫抗体,结果显示3组猪群的抗体合格率分别为33%、78%和100%,疫苗诱导的抗体水平达到农业部规定的动物强制免疫标准。