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氨基糖苷类药物是畜牧业中广泛应用的一类抗生素,在动物源性食品中的残留可能给人体健康带来严重危害。本文综述了动物源性食品中氨基糖苷类药物残留的主要检测方法,并展望了其发展方向。 相似文献
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一 兽药残留的危害
1 对人体健康的影响
(1)毒性作用。如长期食用兽药残留超标的食品,当体内蓄积的药物浓度达到一定量时会使人体产生多种急慢性中毒。(2)致敏作用。试验证明,长期摄入含有抗菌素如青霉素、四环素、磺胺类和某些氨基糖苷类药物残留的动物源性食品.可在一部分人体内发生致敏作用,产生抗体。轻者引起皮肤过敏、瘙痒和荨麻疹,重者引起急性血管性水肿和休克,甚至引起死亡。 相似文献
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四环素类药物是一类广谱抗菌药物,在畜牧业中得到广泛应用。该药物的不合理使用甚至滥用,导致环境及动物源性食品中此类药物残留超标,从而威胁公共卫生安全。液相色谱法及液相色谱串联质谱法是检测畜禽产品中四环素类药物残留的主要方法。这类方法的难点及关键步骤是样品的前处理,也是目前研究的热点。本文就目前动物源性食品中四环素类药物残留色谱及质谱分析法,特别是样品前处理方法的研究进展进行综述。近年来新净化材料、新提取剂及新提取方法不断出现,提升了提取及净化效果,减少了试剂用量,提高了工作效率,并能够同时实现多类药物的提取和检测,有力保障了食品和环境安全。 相似文献
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寄生虫病是较严重的人畜共患病之一,而阿维菌素类药物是目前畜牧业上防治寄生虫病的主要药物。阿维菌素类药物属于大环内酯类抗生素,抗虫药效强大,但也具有神经毒性和发育毒性,脂溶性强,在动物体内分布广泛且代谢周期长,极易造成动物源食品中药物残留的问题,通过食物链危害人类健康。因此,对动物源样品中的阿维菌素类药物残留量进行检测意义重大。目前,应用于动物源样品中阿维菌素类药物残留分析的方法主要有液相色谱-紫外检测法、液相色谱-荧光检测法、酶联免疫吸附法、液相色谱-串联质谱法等。作者对近年来阿维菌素类药物各种检测方法进行了综述,旨在探究各种方法的优劣,为更精准有效地检测动物源食品中阿维菌素类药物的残留提供参考依据。 相似文献
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《中国畜牧兽医》2018,(11)
寄生虫病是较严重的人畜共患病之一,而阿维菌素类药物是目前畜牧业上防治寄生虫病的主要药物。阿维菌素类药物属于大环内酯类抗生素,抗虫药效强大,但也具有神经毒性和发育毒性,脂溶性强,在动物体内分布广泛且代谢周期长,极易造成动物源食品中药物残留的问题,通过食物链危害人类健康。因此,对动物源样品中的阿维菌素类药物残留量进行检测意义重大。目前,应用于动物源样品中阿维菌素类药物残留分析的方法主要有液相色谱—紫外检测法、液相色谱—荧光检测法、酶联免疫吸附法、液相色谱—串联质谱法等。作者对近年来阿维菌素类药物各种检测方法进行了综述,旨在探究各种方法的优劣,为更精准有效地检测动物源食品中阿维菌素类药物的残留提供参考依据。 相似文献
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[]动物源性中药材兽药残留问题是影响动物源性中药材质量安全的主要风险因子之一,服用含有兽药残留的动物源性中药材,不但会降低药效,而且会使人体产生过敏反应和抗生素耐药性等,甚至损害人体器官。加强动物源性中药材兽药残留检测,从源头进行质量控制,使动物源性中药材兽药残留早发现、早预警、早处置,使监管前移,做好风险预测与研判,是当前动物源性中药材质量控制急需解决的问题。本文从动物源性中药材兽药残留检测现状、检测方法研究思路和基质效应评价等方面探讨了兽药残留高通量检测技术的研究与应用,以期为加强动物源性中药材兽药残留高通量检测研究与质量安全控制提供参考。 相似文献
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Reeves PT 《Journal of veterinary pharmacology and therapeutics》2007,30(1):1-17
Residues of veterinary drugs have potential implications for human food safety and international trade in animal-derived food commodities. A particular concern is the slow depletion of residues of some injectable formulations from the site of administration. Licensing authorities have adopted different approaches to the human food safety assessment of injection site residues. European agencies apply the maximum residue limit (MRL) for muscle to muscle at the injection site and specify a withdrawal period sufficient to ensure the ingestion of a 300 g portion of muscle, if comprised entirely of injection site tissue, does not exceed the acceptable daily intake. The agencies in Australia, Canada and the USA also exclude injection site residues from the MRL-setting process. These agencies evaluate the risk to consumers posed by potential acute manifestations resulting from the infrequent ingestion of injection site residues based on acute dietary exposure considerations. While all of these approaches protect the safety of consumers, the adoption of different approaches has potential implications for residue surveillance programs in the international trade in meat. In particular, when an exporting country establishes standards for residues at injection sites based on acute dietary exposure considerations and the importing country assesses these residues against the MRL for muscle, the unnecessary condemnation of meat and disruption to market access may result. The latter may represent a potential economical impost to the exporting country. An internationally harmonized approach to the risk analysis of residues of veterinary drugs at injection sites, which protects the safety of consumers and facilitates the international trade in meat, is needed. 相似文献
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Ochratoxin A (OTA) is an important mycotoxin with potential to reach the human food chain through carry-over of contaminated, mostly cereal-based, feed into animal-derived products. Certain population groups, such as infants and children, are intensive and relatively restricted consumers of some animal-derived products, particularly milk and other dairy products, which may become contaminated with OTA. This review examines the literature on the occurrence of OTA in animal-derived products and discusses the public health and food safety implications of consumption of these products. The risk of OTA contamination of meat, milk, blood and derived products is discussed. 相似文献