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101.
Zorn J Schwamberger S Panzer W Adler H Kolb HJ 《Veterinary immunology and immunopathology》2011,144(1-2):27-35
Human leukocyte antigen (HLA)-haploidentical stem cell transplantation is an opportunity for nearly all patients lacking an HLA matched stem cell donor. However, graft rejection and graft-versus-host disease (GvHD) as well as infectious complications still result in high treatment-related mortality. Here, we used the dog as a preclinical model for the study of tolerance induction with the aim to optimize and to improve a clinical protocol of haploidentical stem cell transplantation. For this purpose CD6-depleted peripheral blood stem cells (PBSCs) were transfused 6d after transplantation of unmodified bone marrow from dog leukocyte antigen (DLA)-haploidentical littermate donors in order to induce immune tolerance. Besides hematopoietic stem cells CD6-depleted PBSC contain, NK cells and a minority of suppressive CD8-positive cells that may suppress activated T lymphocytes. Recipients were conditioned with, cyclophosphamide and antithymocyte globulin (ATG) preceded by a transfusion of donor buffy coat and either 1, 2 or 3 × 3.3 Gy total body irradiation (TBI). Postgrafting immunosuppression was limited to 30 d of cyclosporine and methotrexate. The additional administration of CD6-depleted PBSCs after unmodified marrow could not prevent GvHD, but it may improve engraftment and chimerism after conditioning with 2 × 3.3 Gy TBI. Reasons for incomplete suppression and possible improvements for clinical applications are discussed. 相似文献
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Manfred Kerschberger Günther Franke Werner Schuricht 《Archives of Agronomy and Soil Science》2013,59(1-2):147-164
Die Gehalte für die sechs Schwermetalle Cd, Cr, Cu, Ni, Pb und Zn in landwirtschaftlich relevanten Stoffgruppen (mineralische und organische Düngestoffe, Kulturpflanzen und tierische Produkte) wurden aus Literaturdaten für die beiden statistischen Maßzahlen Mittelwert und Spannweite der Mittelwerte in Übersichtstabellen zusammengefasst. 相似文献
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Eva van Gorsel Nicolas Delpierre Ray Leuning Andy Black J. William Munger Steven Wofsy Marc Aubinet Christian Feigenwinter Jason Beringer Damien Bonal Baozhang Chen Jiquan Chen Robert Clement Kenneth J. Davis Ankur R. Desai Danilo Dragoni Sophia Etzold Thomas Grünwald Lianhong Gu Bernhard Heinesch Lucy R. Hutyra Wilma W.P. Jans Werner Kutsch B.E. Law Monique Y. Leclerc Ivan Mammarella Leonardo Montagnani Asko Noormets Corinna Rebmann Sonia Wharton 《Agricultural and Forest Meteorology》2009,149(11):1919
Micrometeorological measurements of nighttime ecosystem respiration can be systematically biased when stable atmospheric conditions lead to drainage flows associated with decoupling of air flow above and within plant canopies. The associated horizontal and vertical advective fluxes cannot be measured using instrumentation on the single towers typically used at micrometeorological sites. A common approach to minimize bias is to use a threshold in friction velocity, u*, to exclude periods when advection is assumed to be important, but this is problematic in situations when in-canopy flows are decoupled from the flow above. Using data from 25 flux stations in a wide variety of forest ecosystems globally, we examine the generality of a novel approach to estimating nocturnal respiration developed by van Gorsel et al. (van Gorsel, E., Leuning, R., Cleugh, H.A., Keith, H., Suni, T., 2007. Nocturnal carbon efflux: reconciliation of eddy covariance and chamber measurements using an alternative to the u*-threshold filtering technique. Tellus 59B, 397–403, Tellus, 59B, 307-403). The approach is based on the assumption that advection is small relative to the vertical turbulent flux (FC) and change in storage (FS) of CO2 in the few hours after sundown. The sum of FC and FS reach a maximum during this period which is used to derive a temperature response function for ecosystem respiration. Measured hourly soil temperatures are then used with this function to estimate respiration RRmax. The new approach yielded excellent agreement with (1) independent measurements using respiration chambers, (2) with estimates using ecosystem light-response curves of Fc + Fs extrapolated to zero light, RLRC, and (3) with a detailed process-based forest ecosystem model, Rcast. At most sites respiration rates estimated using the u*-filter, Rust, were smaller than RRmax and RLRC. Agreement of our approach with independent measurements indicates that RRmax provides an excellent estimate of nighttime ecosystem respiration. 相似文献
110.
Johannes Stoffels Sebastian Mader Joachim Hill Willy Werner Godehard Ontrup 《European Journal of Forest Research》2012,131(4):1071-1089
Due to high variation in forest communities, forest structure and the fragmentation of the forested area in Central Europe, satellite-based forest inventory methods have to meet particularly high-quality requirements. This study presents an innovative method to combine official forest inventory information at stand level with multidate satellite imagery using a spatially adaptive classification approach for producing wall-to-wall forest cover maps of important tree species and management classes across multiple ownership regions in a heterogeneous low mountain range in Germany. The classification approach was applied to a 5,200-km2 area (about 2,080?km2 of forest land, mostly mixed forests) located in the Eifel mountain range in Central Europe. In comparison with conventional classifiers, our results demonstrate a significant increase in classification accuracy in the order of 12%. The method was tested with ASTER images but holds the potential to be used for regular state forest inventories based on standard and novel earth observation data supplied for instance from the SPOT-5 and RapidEye sensors. 相似文献