排序方式: 共有17条查询结果,搜索用时 468 毫秒
11.
Mitsuhiro IRIE Yoshinori TAKEUCHI Yuzo OHTAKE Hitomi SUZUKI Nao NAGATA Takuma MIYOSHI Yumiko KAGAWA Tetsushi YAMAGAMI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(11):1535-1539
A 13-year-old spayed mixed-breed dog was diagnosed with a gastrointestinal
stromal tumor (GIST) after histopathological examination of an abdominal mass. Five months
after surgical resection of the tumor, we detected the recurrence of GIST with multiple
disseminated abdominal lesions. A sequence analysis of cDNA obtained from a biopsy of the
recurrent tumors revealed a mutation within exon 9 of the c-kit gene
(1523A>T, Asn508Ile), which has been shown to cause ligand-independent
phosphorylation of the KIT protein in GISTs and canine mast cell tumors (MCTs). Upon
detection of the recurrent tumors, we initiated treatment with imatinib mesylate (10
mg/kg, q 24 hr). After 2 months, the dog achieved complete remission. Our findings
indicate that canine GIST, and possibly MCT, may be responsive to molecular-targeted
therapy. 相似文献
12.
Masanao ICHIMATA Shinichiro NISHIYAMA Fukiko MATSUYAMA Eri FUKAZAWA Kei HARADA Ryuzo KATAYAMA Atsushi TOSHIMA Yumiko KAGAWA Tetsushi YAMAGAMI Tetsuya KOBAYASHI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(10):1554
Primary hepatic neuroendocrine tumors (PHNETs) are rare in dogs, and limited information exists about the treatment of these tumors. A 12-year-old castrated male French bulldog was presented to our clinic with gastrointestinal signs. Diagnostic tests revealed increased hepatic enzyme levels, a mass in the hepatic quadrate lobe, multiple intrahepatic nodules, and enlarged hepatic hilar lymph nodes. The liver mass was diagnosed cytologically as a malignant epithelial tumor suspected to be of neuroendocrine origin. The dog was treated with single-agent toceranib phosphate (TOC) and survived 25.1 months after the initial presentation. On necropsy, a liver mass was found and was subsequently diagnosed as a PHNET on histopathology. To the best of our knowledge, this is the first report of long-term survival in a dog with PHNET treated with TOC. 相似文献
13.
Kazuki OKADA Shinjiro AMANO Yoshio KAWAMURA Yumiko KAGAWA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(10):1311-1313
An 8-year-old, spayed, female Shiba dog was presented to a referring veterinarian with a
complaint of chronic diarrhea and anorexia. Ultrasound and radiographs revealed an
irregular mass in the pelvic cavity. The mass and the affected section of colon were
surgically removed. Histopathological examination revealed multifocal coalescing
granulomas and effaced intestinal structures. Central necrotic debris surrounded by
multinucleated giant cells, lymphocytes, plasma cells and neutrophils was observed.
Numerous, irregularly branched hyphae with pale basophilic, thin walls and occasional
bulbous enlargements at the tips were present. Polymerase chain reaction identified
Basidiobolus ranarum, successfully confirming a definitive diagnosis of
basidiobolomycosis. To the best of our knowledge, this is the first report of intestinal
basidiobolomycosis in a dog. 相似文献
14.
Yumiko KAGAWA Yuko NAKANO Tetsuya KOBAYASHI Kazushi ASANO Satoshi TAKAGI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(12):1659-1661
Nineteen cases of histiocytic sarcomas in Pembroke Welsh Corgi were examined
histopathologically. Focal or multiple masses were detected in the lung or in regional
lymph nodes, or in both lung and nodes. All neoplastic lesions had common histological
features characterized by the proliferation of pleomorphic histiocytic cells combined with
various inflammatory cells. Most of the pleomorphic neoplastic cells were immunopositive
for human leukocyte antigen (HLA)-DR and Iba-1. The median survival time for all dogs was
133 days. In the present study, several prognostic factors, such as gender, age, single or
multiple lesions, lymph node involvement at the time of diagnosis, surgical resection
status and additional chemotherapy, were examined, although none of these factors
approached statistical significance. Histiocytic sarcoma must be considered in the
differential diagnosis of dogs with pulmonary masses, especially in the canine breed. 相似文献
15.
16.
17.
Masayuki YAMAMOTO Hiroyasu MAKINO Tetsushi KAGAWA Osamu TOMINAGA 《Fisheries Science》2004,70(6):1089-1097
ABSTRACT: The occurrence and distribution of larval and juvenile Japanese flounder Paralichthys olivaceus and major demersal fish from May to September were examined at seven sandy beaches at the central Seto Inland Sea. The flounder appeared from late May to August and were mainly collected at a depth of 2–5 m. Settlement of larval flounder was seen from late May to late June. A total of 6412 individuals of 17 species representing 12 families were collected in the study area. The dominant fish species were Favonigobius gymnauchen (56.0%), Tarphops oligolepis (8.1%), Rudarius ercodes (7.8%), P. olivaceus (7.3%), Repomucenus spp. (7.0%) and Heteromycteris japonica (3.3%). The catches of flounder differed among beaches and months. The number of flounder in June at Ohama Beach, where the most flounder were collected, was 22.6 individuals per haul (400 m2 ). The density of the flounder correlated negatively to that of F. gymnauchen . 相似文献