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Takeshi OHTA Shuichi KIMURA Masaya HIRATA Takahisa YAMADA Toshie SUGIYAMA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(10):1327-1330
The Spontaneously Diabetic Torii (SDT) fatty rat, a model for obese type 2 diabetes,
shows bone quantitative abnormalities, namely low bone mineral density (BMD). The
objective of this study was to evaluate bone morphological changes, in particular
identifying the bone qualitative abnormalities, in the SDT fatty rat. Male SDT fatty rats
showed increases in total trabecular area and trabecular number and decreases in
trabecular thickness in cancellous bones of the proximal tibia, indicating trabecular
miniaturization. The SDT fatty rat is useful for investigation of pathophysiological
changes in bone quality in diabetic osteoporosis. 相似文献
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The increased mental stress of daily life and aging of the population are serious matters in Japan. There are many studies regarding the effects of human-animal interactions on mental and physical human health, whereas there are few studies examining the effects of visiting zoos. To determine the effect of visiting zoos on human health and quality of life, two different zoos were visited by 70 participants in Experiment 1 and 163 participants in Experiment 2. In this study we administered the WHO QOL-26 questionnaire in Japanese to assess the psychological scales of participants, and blood pressures and pulse rates were measured to assess their physical scales. We also used pedometers to count the number of steps taken during zoo visits. Both zoo visits decreased blood pressure and participants demonstrated more than 6000 steps during each visit. The quality of life sub-scale scores were improved after zoo visits. 相似文献
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Akihiro MATSUURA Emiko OHTA Koichiro UEDA Hiroki NAKATSUJI Seiji KONDO 《Journal of Equine Science》2008,19(1):9-18
To obtain basic knowledge about selecting horses for therapeutic riding, the influence of
equine conformation on rider oscillation and relationships between these factors and the
evaluation on horses as the therapeutic riding were studied. Thirty-five riding horses
were used. Equine conformation was estimated by 24 indices. Rider oscillation was measured
by an accelerometer fixed at the rider’s waist. The spatial position of the oscillation
was estimated by a double integration of the acceleration. Horses were evaluated for
therapeutic riding by a Riding for the Disabled Association instructor as a rider.
Evaluations were on a scale of 1 to 5, with 5 being the highest score for 27 items. Horses
were classified into 4 groups: the short and narrow (SN), short and wide (SW), tall and
narrow (TN), and tall and wide (TW). The frequencies of rider oscillation both at walk and
trot were higher (P<0.01), and the vertical (P<0.01) and longitudinal (P<0.05)
amplitudes at trot were smaller, on short horses than on tall horses. The vertical
amplitude at walk was smaller (P<0.05) and the lateral amplitude at trot was larger
(P<0.01) on wide horses than on narrow horses. Short horses could be used for the rider
who requires side walkers. Wide horses could be used for relieving muscular tension and
for the rider who could not maintain good balance on the horse. Short and wide horses
should be suitable for therapeutic riding. 相似文献
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Kenichi MATSUI Takeshi OHTA Hisayo MORINAGA Tomohiko SASASE Sumiaki FUKUDA Makoto ITO Masatoshi UEDA Naoto OGAWA Katsuhiro MIYAJIMA Mutsuyoshi MATSUSHITA 《Animal Science Journal》2008,79(5):605-613
Spontaneously Diabetic Torii (SDT) fatty rats, made by introducing the fa allele of the Zucker fatty rat into the SDT rat genome, represent a new model of obese type 2 diabetes. SDT fatty fa/fa (SDT fatty) rats exhibit overt obesity, hyperglycemia, and hyperlipidemia from about six weeks of age, and this is associated with hyperphagia by an induced disorder of leptin action. The present study was conducted to elucidate whether suppression of hyperphagia can improve reduce abnormalities in SDT fatty rats. SDT fatty rats were subjected to pair-feeding with SDT fatty +/ + (SDT) rats from 6 to 26 weeks of age, and the effects on metabolic parameters and diabetic complications were assessed. Body weights of the pair-fed rats were similar with those of SDT rats during the experimental period. Improvement of hyperglycemia or hypertriglyceridemia was observed from 8 to 16 or 12 weeks of age in the pair-fed rats, but hypercholesterolemia was not entirely improved during the experimental period. We also examined mRNAs expression in liver, and found that the expression associated with glyconeogenesis, such as glucose-6-phosphatase (G-6-Pase) and phosphoenolpyruvate carboxykinase (PEPCK), tended to decrease in the pair-fed rats, and the mRNA expression of hydroxymethylglutaryl-CoA (HMG-CoA) was elevated. Renal parameters, such as blood urea nitrogen and urinary albumin excretion, were improved in the pair-fed rats. The incidence or progression of diabetic complications, such as renal lesions and cataract, was reduced. In conclusion, suppression of hyperphagia in SDT fatty rats was effective in temporally improving hyperglycemia or hypertriglyceridemia, and reducing the incidence or progression of diabetic complications, but was ineffective in reducing hypercholesterolemia. 相似文献
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KENSUKE NAKAMURA SATOSHI TAKAGI NOBORU SASAKI WICKRAMASEKARA RAJAPAKSHAGE BANDULA KUMARA MASAHIRO MURAKAMI HIROSHI OHTA MASAHIRO YAMASAKI MITSUYOSHI TAKIGUCHI 《Veterinary radiology & ultrasound》2010,51(1):79-85
In six normal beagles and 27 dogs with spontaneous focal or multifocal liver lesions, contrast-enhanced ultrasonography using Sonazoid® was performed. Sonazoid® is a newly developed second-generation contrast agent with the ability to be used for real-time contrast imaging along with parenchymal imaging. An appropriate protocol for the evaluation of all three phases (arterial, portal, and parenchymal) was established based on the results for normal beagles. By evaluation of the echogenicity of hepatic nodules during the arterial and parenchymal phases it was possible to differentiate malignant tumors from benign nodules with very high accuracy. In 15 of 16 dogs diagnosed as malignant tumors, nodules were clearly hypoechoic to the surrounding normal liver during the parenchymal phase. Additionally, malignant tumors had different echogenicity compared with the surrounding normal liver during the arterial phase in 14 of 15 dogs. In the portal phase, there were no characteristic findings. Contrast-enhanced ultrasonography with Sonazoid® appears to improve the characterization of canine focal and multifocal hepatic lesions. 相似文献
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Dugar DELGERMURUN Shigeo ITO Toshio OHTA Soichiro YAMAGUCHI Ken-ichi OTSUGURO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2016,78(1):71-76
Chemoreceptor cells aggregating in clusters in the chicken thoracic aorta
contain 5-hydroxytryptamine (5-HT) and have voltage-dependent ion channels and nicotinic
acetylcholine receptors, which are characteristics typically associated with neurons. The
aim of the present study was to investigate the effects of 5-HT uptake inhibitors,
fluvoxamine, fluoxetine and clomipramine (CLM), and amphetamine derivatives,
p-chloroamphetamine (PCA) and methamphetamine (MET), on endogenous 5-HT
outflow from the isolated chick thoracic aorta in vitro. 5-HT was
measured by using a HPLC system with electrochemical detection. The amphetamine
derivatives and 5-HT uptake inhibitors caused concentration-dependent increases in
endogenous 5-HT outflow. PCA was about ten times more effective in eliciting 5-HT outflow
than MET. The 5-HT uptake inhibitors examined had similar potency for 5-HT outflow. PCA
and CLM increased 5-HT outflow in a temperature-dependent manner. The outflow of 5-HT
induced by PCA or 5-HT uptake inhibitors was independent of extracellular Ca2+
concentration. The 5-HT outflow induced by CLM, but not that by PCA, was dependent on the
extracellular NaCl concentration. These results suggest that the 5-HT uptake system of
5-HT-containing chemoreceptor cells in the chicken thoracic aorta has characteristics
similar to those of 5-HT-containing neurons in the mammalian central nervous system
(CNS). 相似文献