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观察阿司匹林丁香酚酯对大鼠血液学成分及血液生化指标成分的影响,为其临床开发应用提供依据。选择成年健康W istar大鼠随机分为4组:空白对照组、阿司匹林丁香酚酯组、阿司匹林对照与丁香酚药物对照组,连续灌服相应药物2周,在最后1次灌药后每组各取1/2大鼠,股动脉取血,留下的1/2动物停止给药后继续观察1周再取血。采用全自动血液分析仪与全自动血液生化分析仪测定大鼠的红细胞、血小板、甘油三酯、总胆固醇、碱性磷酸酶等血液学、血清生化各项指标。结果:阿司匹林丁香酚酯对大鼠血液成分及血液生化有一定的影响,且影响较阿司匹林小;具有显著降低大鼠血清甘油三酯、总胆固醇含量的作用,且强于阿司匹林与丁香酚。试验表明阿司匹林丁香酚酯对血液及血液生化指标影响较低,较对照药具有更好的药用价值。 相似文献
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炎毒热清及其微乳制剂小鼠急性毒性试验和体外抑菌作用(英文) 总被引:14,自引:0,他引:14
[Objective] The aim of this study is to evaluate the safety and bacteriostasis of Yandureqing(AEE)and its microemulsion(AEE-ME).[Method]The acute toxicity was tested in mice by intragastric administration,and median lethal dose(LD50)as well as its 95% confidence interval was calculated by modified Karber method;the bacteriostasis was investigated by cylinder plate method.[Result]LD50 of AEE in mice was 10.937 g/kg with the 95% confidence interval of 9.309-12.850 g/kg;and LD50 of AEE-ME in mice was 5.357 g/kg with the 95% confidence interval of 4.388-6.566 g/kg.The MICs of AEE to Escherichia coli O149 from swine,Staphylococcus aureus,Salmonella pullorum and Streptococcus agalactiae were 10.00,20.00,20.00 and 10.00 mg/ml,respectively;while the MICs of AEE-ME to the 4 kinds of bacteria mentioned above were 5.00,10.00,5.00 and 5.00 mg/ml in turn,and that to Pseudomonas aeruginosa is 20.00 mg/ml.[Conclusion]AEE is an actually nontoxic drug and AEE-ME belongs to the low toxic preparation.AEE and AEE-ME have obvious bacteriostasis,in which AEE-ME is superior to AEE. 相似文献
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