鲤鱼急性喹乙醇中毒的病理学研究

试验对鲤鱼进行了喹乙醇急性中毒的病理学研究。喹乙醇对鲤鱼 (60± 5g)口服给药的LD50 为 :32 4 9 4mg/kg体重。中毒鱼表现出特征性的“应激性出血症” ,鳍条基部、嘴部和腹部充血、出血发红 ,肠道排出白色半透明粘液便 ,临死前出现明显的神经症状。病理组织学上 ,肝脂肪变性或水泡变性及凝固性坏死 ,肾上腺空泡变性 ,肠呈卡他性肠炎 ,肾小管上皮细胞、心肌纤维空泡变性 ;鳃小片水肿 ,上皮增生、变性、坏死和脱落。超微结构上 ,心肌、肝和肾小管上皮细胞的线粒体肿胀 ,嵴断裂、溶解 ,肝细胞内糖原颗粒减少。中毒早期肠上皮微绒毛断裂 ,脱落 ,随着病程的发展肠上皮细胞变性、坏死、脱落。

Pathological Study on the Acute Olaquindox Poisoning in Carp

The pathology of the acute olaquindox poisoning in carp was studied.The LD 50 of the olaquindox to carp was 3 249 4mg/kg body weight by oral.The clinic symptom of the poisoned fish was characterized by"the stress hemorrhage syndrome".The fish showed hyperemia and hemorrhage at the base of the fins,in the mouth and the abdomen.The poisoned fish excreted opalescent translucent mucous faeces.The nervous signs appeared before death.The pathological lesions showed as hyperemia and hemorrhage in the dermis,fatty or vacuolar degeneration and necrosis in the liver cells,catarrhal inflammation in the intestines,vacuolar degeneration in the renal tubular epithelial cells and the cardiac muscle cells,hyperplasia,degeneration,necrosis and desquamation in the gill lamella epithelium.Ultra structurally,the mitochondria of the cardiac muscle cells,the liver cells and the renal tubular epithelial cells swelled with disintegration and lyses of the cristaes.The glycogen decreased in the liver cells.The intestinal epithelium microvillis collapsed and desquamated at the first stage of the test,and then many intestinal epitheliums necrosed and desquamated.