CAV与REV共感染SPF鸡对疫苗免疫反应的抑制作用

用1日龄SPF鸡人工感染鸡贫血病毒(CAV)和禽网状内皮增生病病毒(REV),探讨病毒感染对鸡体疫苗免疫反应的影响。结果表明,在用禽流感病毒(AIV,H5和H9)疫苗免疫后,CAV与REV单独感染均显著抑制了鸡体对H5和H9亚型禽流感病毒灭活疫苗的HI抗体反应,在CAV与REV共感染后,这种抑制作用更为明显。CAV单独感染后鸡体对新城疫病毒(NDV)和传染性法氏囊病病毒(IBDV)疫苗的免疫反应受到抑制,但与对照组在统计学上的差异不显著,然而,CAV可以显著加重REV感染对鸡体在NDV和IBDV疫苗免疫后抗体反应的抑制作用。从而证实CAV与REV共感染在疫苗免疫抑制上有协同作用。

Synergic inhibitory effect of co-infection of CAV and REV on immune responses to vaccines in SPF chickens

Chicken anemia virus (CAV) and reticuloendotheliosis virus (REV) were used to infect 1-day-old SPF chickens.The results showed that HI antibody titers to avian influenza virus (AIV) H5 and H9 were significantly lower in SPF chickens inoculated with CAV or REV alone at the age of 1 day than the control after vaccination of inactivated vaccines of AIV,and HI titers in birds co-infected with both viruses were even more lower than those of the birds infected with CAV or REV alone.CAV infection tended to decrease the antibody responses to vaccines against Newcastle disease virus (NDV) and infectious bursal disease virus (IBDV),but differences were not significant statistically.However,co-infection of CAV with REV significantly suppressed the antibody titers to NDV and IBDV compared with chickens infected with REV alone,demonstrating the synergism in immunosuppression in chickens co-infected with CAV and REV.