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喹乙醇在动物血浆与组织间残留分布规律研究及相关性分析
引用本文:张锦红,曾昭智,葛长荣.喹乙醇在动物血浆与组织间残留分布规律研究及相关性分析[J].中国动物保健,2011,13(5):13-15.
作者姓名:张锦红  曾昭智  葛长荣
作者单位:1. 广东药学院实验动物中心,广东,广州,510008
2. 云南农业大学动物营养与饲料重点实验室,云南,昆明,650201
基金项目:国家科技支撑计划资助项目,国家科技部攻关项目资助
摘    要:试验采用高效液相色谱分析法,对饲喂含有不同浓度喹乙醇饲料(75mg/kg、100mg/kg、125mg/kg)的猪体组织(肝脏、肾脏、肌肉)和血浆中喹乙醇含量进行检测,分析喹乙醇在猪体内的残留分布,探讨喹乙醇在血浆中的含量与猪体内组织的残留含量的相关性。结果表明:饲料中喹乙醇添加量与组织和血浆中残留量均呈线性相关关系;同一浓度的喹乙醇添加量在猪组织和血浆中的残留量分布:肝脏>肾脏>肌肉>血浆;建立的血浆与组织间残留量的回归方程具有较高的可靠性。

关 键 词:喹乙醇  高效液相色谱  残留分布  相关性

Analysis on the distribution and correlation of residues of Olaquindox in animal plasma and tissue
Zhang Jinhong,Zeng Zhaozhi,Ge Changrong.Analysis on the distribution and correlation of residues of Olaquindox in animal plasma and tissue[J].China Animal Health,2011,13(5):13-15.
Authors:Zhang Jinhong  Zeng Zhaozhi  Ge Changrong
Institution:z (l.Laborotory Animal Centre of Guangdong Pharmaceutical College, Guangzhou, China; 2.Yunnan Animal Nutrition and Feed Key Lab, Kunming,China)
Abstract:Using high performance liquid chromatography, detected the content of Olaquindox in tissue (liver, kidney, muscle) and plasma of pig which fed with different concentrations of Olaquindox feed (75mg/kg, 100mg/kg, 125mg/kg). Studied on the correlation of residues of Olaquindox in animal plasma and tissue and the distribution of residues in the body. Results showed that there is a linear correlation between the amount of O- laquindox in feed and the residues in plasma and tissues, The residual distribution of the same concentration Olaquindox in pig tissue and plasma is: liver〉 Kidney〉 muscle〉 plasma. There is a high reliability for estab- lishing the regression equation of the residues in plasma and tissue.
Keywords:Olaquindox  high performance liquid chromatography  residual distribution  correlation
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