银黄颗粒中黄芩甙在大鼠体内的测定及药代动力学

目的：考察银黄制剂的药动学特征。方法：建立测定大鼠血浆中黄芩甙的高效液相色谱法（HPLC），并以银黄颗粒为代表进行药代动力学研究。结果：黄芩甙经直肠灌注比灌胃血药浓度高、消除速率慢；黄芩甙经灌胃会产生首过代谢作用，同时在用药后约600min出现双峰现象；银黄颗粒中的黄芩甙受其它成分的影响不明显，在大鼠体内的药动学过程与单体黄芩甙基本一致。结论：用建立的HPLC法进行银黄颗粒的药代动力学研究，方法简单、准确、快速。并且获得的药代动学参数具有一定临床应用价值。

Determination and pharmacokinetics of baicalin in rats dosed with Yinhuang granule

Aim：To understand the pharmacokinetic characteristics of Yinbuang preparations.Mehtods：A high performance liquid chromatographic （HPLC） method was established to determine the contents of baicalin in rats plasma after they were given Yinhuang granule by oral and rectum respectively.Results：The baicalin of rectal administration had higher plasma concentration and slower climination rate than that of oral administration,while the latter had first-pass metaholism and gave a second peak at about600min.Thie basicalin in Yinhuang granule was little affected by over compositions and its pharmacolineties was basionally conaistent with that of the monomer baicalin.Conclusion：The developed HPLC method is simple,accurate and quick for the pharmacukimetic study of Yinbuang granule.The obtained pharmacolinetic parameters are valuable for clinical application,