| TGF-β系统及其在硬骨鱼中的研究进展 |
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| 引用本文： | 詹绪良,吴金英,李文笙.TGF-β系统及其在硬骨鱼中的研究进展[J].南方水产,2013,9(3):90-96. |
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| 作者姓名： | 詹绪良 吴金英 李文笙 |
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| 作者单位： | 中山大学生命科学学院水生经济动物研究所,广东省水生经济动物良种繁育重点实验室,广东广州5 10275 |
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| 基金项目： | 现代农业产业技术体系(罗非鱼体系)专项资金，公益性行业(农业)科研专项 |
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| 摘 要： | TGF-β（transforming growth factor-β）是一类多效应细胞因子，在很多生理活动中发挥功能。TGF-β以前体形式合成，随后被切割活化形成成熟的TGF-β。TGF-β以二聚体的形式发挥作用，与受体TβRI（transforming growth factor-β receptor I）和TβRII（transforming growth factor-β receptor Ⅱ）形成一个大型复合物后，磷酸化胞内的Smad，激活下游信号通路。鱼类中，对TGF-β家族成员的研究主要集中在对TGF-β1的研究，包括TGF-β1与免疫相关和与生殖相关的功能，也有研究表明TGF-β1与肝功能相关。此外，有少量对TGF-β家族其他成员和TGF-β受体的研究。
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| 关 键 词： | TGF-β TGF-β受体 硬骨鱼 |
TGF-β system and its research advances in teleost |
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| ZHAN Xuliang
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WU Jinying
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LI Wensheng.TGF-β system and its research advances in teleost[J].South China Fisheries Science,2013,9(3):90-96. |
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| Authors: | ZHAN Xuliang WU Jinying LI Wensheng |
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| Institution: | Guangdong Provincial Key Lab. for Aquatic Economic Animals; Institute of Aquatic Economic Animals School of Life Sciences, Sun Yat-sen University, Guangzhou 510275,China |
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| Abstract: | Transforming growth factor-β （TGF-β） family members are multi-functional cytokines, which play pivotal roles in many physiological activities. TGF-β is synthesized as a pro-TGF-β precursor. Subsequently, the N-terminus of the immature protein is removed, and the new proteins form a homodimer. TGF-β mediates its biological functions via binding to receptors TβRI and TβRII, and then phosphorylates intracellular Smad proteins to activate signal pathway. Till now, most researches in TGF-β family are focused on TGF-β1, which is involved in immune, reproductive and liver functions, while just few studies about the other members of TGF-β and TGF-β receptors exist. |
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| Keywords: | TGF-β TGF-β receptor teleost |
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