| 一株鸡传染性法氏囊病病毒基因组测序及其分子特征 |
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| 引用本文： | 祁小乐,高立,秦立廷,邓小芸,吴关,张礼洲,余飞,任宪刚,高玉龙,高宏雷,王永强,王笑梅.一株鸡传染性法氏囊病病毒基因组测序及其分子特征[J].农业科学与技术,2011(12):1946-1949. |
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| 作者姓名： | 祁小乐 高立 秦立廷 邓小芸 吴关 张礼洲 余飞 任宪刚 高玉龙 高宏雷 王永强 王笑梅 |
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| 作者单位： | 中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室禽传染病研究室 |
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| 基金项目： | Supported by National 973 Project(2005CB523202);National Natural Science Foundation of China (30901083);China PostdoctoralScience Foundation(20080440921)~~ |
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| 摘 要： | 目的]测定一株鸡传染性法氏囊病病毒基因组序列及其分子特征。方法]分离出一株具有特殊分子特征的鸡传染性法氏囊病病毒（IBDV）超强毒株（vvIBDV）HLJ-0504,并对其基因组进行了克隆和测序。结果]序列分析显示,HLJ-0504的基因组A节段属于超强毒株,而其B节段则来源于另外一个独特的祖先。动物实验表明,HLJ-0504对SPF雏鸡的致病率和致死率分别为100%和86.7%。结论]具有独特基因组B节段的vvIBDV仍在我国流行,我国IBDV的进化特征存在多样性。IBDV的毒力不是由基因组的A或B单独决定的。
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| 关 键 词： | 鸡传染性法氏囊病病毒（IBDV） 基因组 进化 毒力 |
Genomic Sequencing and Molecular Characteristics of A Very Virulent Strain of Infectious Bursal Disease Virus Isolated in China |
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| QI Xiao-le,GAO Li,QIN Li-ting,DENG Xiao-yun,WU Guan,ZHANG Li-zhou,YU Fei,REN Xian-gang,GAO Yu-long,GAO Hong-lei,WANG Yong-qiang,WANG Xiao-mei.Genomic Sequencing and Molecular Characteristics of A Very Virulent Strain of Infectious Bursal Disease Virus Isolated in China[J].Agricultural Science ＆ Technology,2011(12):1946-1949. |
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| Authors: | QI Xiao-le GAO Li QIN Li-ting DENG Xiao-yun WU Guan ZHANG Li-zhou YU Fei REN Xian-gang GAO Yu-long GAO Hong-lei WANG Yong-qiang WANG Xiao-mei |
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| Institution: | ** Division of Avian Infectious Diseases,State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin 150001 |
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| Abstract: | Objective] The paper was to determine the genomic sequence of a very virulent strain of infectious bursal disease virus(IBDV),and study its molecular characteristics.Method] A very virulent strain(vvIBDV)(HLJ-0504) of infectious bursal disease virus(IBDV) with special characters was isolated in China and its genome was sequenced.Result] Sequence analysis showed that segment A of HLJ-0504 was derived from vvIBDV,while segment B was from a distinct ancestor.The morbidity and mortality of HLJ-0504 was 100% and 86.7%to SPF chickens,respectively.Conclusion] vvIBDV with distinct segment B were still circulating and the evolution of IBDV was diversified in China.Besides,it is hard to imagine that the virulence of IBDV is determined solely by segment A or B. |
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| Keywords: | Infectious bursal disease virus(IBDV) Genome Evolution Virulence |
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