免疫系统对营养代谢的调节

 营养和免疫的相互作用多种多样,对动物的生长和生产有着深远的影响。天然免疫系统在感染初期对机体提供保护, 同时调节很多营养代谢的变化。巨噬细胞是天然免疫细胞的主要感觉和调节细胞。前炎症细胞因子不仅针对病原体调整局部免疫,而且也改变全身代谢的动态平衡,降低采食量和生长率, 能量、氨基酸、脂肪与矿物质代谢的改变具有重要的营养意义。免疫系统产生的调节因子可改变全身的营养分配和阻止与生长有关的代谢过程。论述了在免疫应答中,能量、氨基酸、脂肪和微量元素代谢在数量方面的重要变化。

Regulation of Nutrient Metabolism by the Immune System

Interactions between nutrition and immunity are diverse and have profound implications on animal growth and productivity. The innate immune system provides protection during the initial stages of infection and is responsible for mediating many of the alterations in nutrient metabolism. The macrophage is the key sensory and regulatory cell of the innate immune system. Their pro - inflammatory cytokines coordinate local immunity to pathogens, yet also act systemically to alter metabolic homeostasis and decrease food intake and growth rate. Altered energy, amino acid, lipid, and mineral metabolism have nutritionally important implications. Regulatory factors produced by the immune system have systemic effects to alter nutrient partitioning and deter the metabolic processes associated with growth. This paper described ,quantitatively important changes in energy, amino acid, lipid and trace mineral metabolism accompany immune responses.