| 食药用真菌翅鳞伞菌丝体蛋白活性的研究 |
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| 引用本文： | 汪建敏,焦阳,吕凤霞,别小妹,王煜,陆兆新.食药用真菌翅鳞伞菌丝体蛋白活性的研究[J].江西农业学报,2008,20(8):99-101. |
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| 作者姓名： | 汪建敏 焦阳 吕凤霞 别小妹 王煜 陆兆新 |
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| 作者单位： | 南京农业大学,食品科技学院,江苏,南京,210095 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 对翅鳞伞菌丝体的胞内粗蛋白进行分离、纯化、筛选，获得了抗水稻纹枯病菌的翅鳞伞纯化菌丝体蛋白PSPB-2。通过荧光显微镜观察PSPB-2对人肺癌细胞株（A549）的影响，发现PSPB-2会引起A549出现典型的细胞凋亡现象。进一步研究发现PSPB-2有限制性核酸内切酶的活性。说明菌丝体蛋白PSPB-2具有抗真菌作用的同时又具有抗肿瘤作用。
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| 关 键 词： | 翅鳞伞 抗肿瘤蛋白 抗真菌 核酸内切酶 |
Study on Activity of Mycelium Proteins from Pholiota squarrosa |
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| WANG Jian-min,JIAO Yang,LU Feng-xia,BIE Xiao-mei,WANG Yu,LU Zhao-xin.Study on Activity of Mycelium Proteins from Pholiota squarrosa[J].Acta Agriculturae Jiangxi,2008,20(8):99-101. |
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| Authors: | WANG Jian-min JIAO Yang LU Feng-xia BIE Xiao-mei WANG Yu LU Zhao-xin |
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| Institution: | WANG Jian-min,JIAO Yang,LU Feng-xia,BIE Xiao-mei,WANG Yu,LU Zhao-xin(College of Food Scientific Technology,Nanjing Agricultural University,Nanjing 210095,China) |
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| Abstract: | Mycelium protein PSPB-2 was separated,purified and screened from the mycelium proteins of Pholiota squarrosa.PSPB-2 remarkably inhibited the human lung cancer cell line A549 through observation by fluorescence microscope.PSPB-2 had antifungal activity to A549.And the further research showed that PSPB-2 had inhibition to endonuclease.So mycelium protein PSPB-2 had the antitumor activity as well as antifungal activity. |
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| Keywords: | Pholiota squarrosa Antitumor protein Antifungal Endonuclease |
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