吡喹酮在绒山羊体内药代动力学的研究

应用反相高效液相色谱法测试了 6只健康绒山羊以每千克体重 10 0mg剂量口服给药后吡喹酮在体内的血药浓度 ,并进行了药代动力学研究 ,应用非线性最小二乘法处理 ,实验数据参数用一室模型描述。在口服给药后 ,经过短暂的迟滞期 Lagtime =(0 2 3987± 0 0 95 39)h],血药浓度迅速上升 ,吸收相很快完成t1/ 2ka=(0 33899± 0 192 94)h],达峰时间tp=(1 6 45 6 8± 0 43788)h ,之后是一缓慢的消除相 t1/ 2kel=(6 2 3789± 0 70 6 2 7)h],表观分布容积Vd=(2 3 6 8130± 13 16 197)L/kg ,机体清除率CLB =(2 6 2 3 46±1 473 10 )mg/(kg·h) ],药时曲线下面积AUC =(5 0 0 73 2 7± 2 6 12 482 ) μg/(mL·h) ],最高血药浓度Cmax=(4 89990± 2 830 6 4) μg/mL。对吡喹酮在绒山羊体内血药浓度实测值与理论值进行卡平方检验 ,结果表明二者之间没有显著性差异 (P >0 0 5 )。

Pharmacokinetics Study of Praziguantel after Oral Administration in Cashmere Goat

The drug concentration of plaziquantel in plasma were determined by high performance liquid chromatography（HPLC）and the pharmacokinetics of praziquantel were determined after oral administration of 100　mg/kg of body weight to six cashmere goats using nonlinear least squares regression methods．Data obtained were best described by one compartment open model．After dosing there is a short lagtime ［Lagtime=（0.23987±0.09539）h］．Then plasma concentration of praziguantel increased rapidly. And the absorption phase was quickly completed ［t1/2ka=（0.33899±0.19294）h］．The time of peak (tp) is described as tp=（1.64568±0.43788）h．After peak, there is long clearance phase ［t1/2kel=（6.23789±0.70627）h］．The apparent volume of distribution Vd=（23.68130±13.16197）L／kg．The mean body clearance rate　CLB=［（2.62346±1.47310）mg/（kg*h）］．The area under curve of concentration time AUC=［（50.07321±26.12482）μg/（mL*h）］．The maximal plasma concentration Cmax=（4.89990±2.83064）μg／mL． No significant difference was found between the measured values and theoretically predicted values in the plasma concentration of praziquantel (P>0.05)．