土霉素在大菱鲆体内药代动力学及残留消除规律研究 |
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作者姓名: | 曲志娜 郑增忍 赵思俊 邹明 路平 李存金 谭维泉 孙晓亮 |
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作者单位: | [1]中国动物卫生与流行病学中心,青岛266032 [2]青岛农业大学动物科技学院,青岛266109 |
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摘 要: | 首次研究大菱鲆口服土霉素的药代动力学特征及残留消除规律.采用高效液相色谱法,对以80mg/kgb.W.单剂量口灌土霉素的大菱鲆进行连续采样监测.结果表明,土霉素在大菱鲆血液、肌肉、肝脏中药代动力学特征分别符合带时滞的一级吸收二室开放模型、带时滞的一级吸收二室开放模型和带时滞的一级吸收一室开放模型.土霉素在大菱鲆体内消除速度较慢,16℃水温的实验条件下,在大菱鲆肌肉、肝脏中的休药期分别为28d和10d.
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关 键 词: | 土霉素 大菱鲆 药代动力学 消除 高效液相色谱法 |
Study on Pharmacokinetic and Eliminate of Oxytetracycline in Turbot |
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Authors: | Zheng Zenren Zhao Sijun Zou Ming Lu Ping Li Cunjin Tan Weiquan Sun Xiaoliang Qu Zhina |
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Abstract: | Abstract: This article is the first to study on pharmacokinetic and eliminate of OTC in turbot after oral administration. The residue of OTC in turbot which was exposured to 80 mg/kg b.w. OTC solution was monitored continually by HPLC. Pharmacokinetic studies showed that the concentration-time course of the drug conformed to the characteritics of the two compartment open model with the first order absorption and a lagtime for the blood and the muscle, and the one compartment open model with first order absorption and a lagtime for the liver. OTC was slowly eliminated in turbot. The concerntration of OTC in the muscle was below LOD after 28d , and the concerntration of OTC in the liver was below LOD after 10d. |
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Keywords: | Key words: OTCzz Turbotzz Pharmacokineticzz Eliminatezz HPLC zz |
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