| 连芩解毒颗粒提取工艺研究 |
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| 作者姓名： | 邓桂明 何海 葛金文 肖小芹 陈镇 张志国 吴萍 戴冰 欧阳林旗 肖望重 向彪 |
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| 作者单位： | 湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学中西医结合学院, 湖南 长沙 410208,湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学中西医结合学院, 湖南 长沙 410208,湖南中医药大学中西医结合学院, 湖南 长沙 410208,湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学第一附属医院, 湖南 长沙 410007,湖南中医药大学第一附属医院, 湖南 长沙 410007 |
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| 基金项目： | 湖南省科技厅博士后基金项目（2014RS4013）；2014年湖南省人力资源和社会保障厅博士后研究人员日常经费资助项目；张志国全国名老中医药专家传承工作室建设项目（国中医药人教教育[2016]。 |
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| 摘 要： | 目的 优选连芩解毒颗粒的最佳提取工艺。方法 以盐酸小檗碱及黄芩苷的转移率为考察指标，结合单因素及正交试验法，对连芩解毒颗粒的提取工艺进行优化。结果 优选出连芩解毒颗粒的最佳提取工艺为：药材用60%乙醇浸泡1.0 h，回流提取2次，第一次1.5 h，料液比1∶10（g∶mL），第二次1 h，料液比1∶8（g∶mL）。结论 优选的提取工艺稳定、可行，为连芩解毒颗粒的生产制备提供实验依据。
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| 关 键 词： | 连芩解毒颗粒 正交试验 提取工艺 盐酸小檗碱 黄芩苷 |
| 收稿时间： | 2015/11/30 0:00:00 |
Study on the Extraction Process of Lianqin Jiedu Granule |
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| Authors: | DENG Guiming HE Hai GE Jinwen XIAO Xiaoqin CHEN Zhen ZHANG Zhiguo WU Ping DAI Bing OUYANG Linqi XIAO Wangzhong and XIANG Biao |
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| Institution: | The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;The College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,The College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China,The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China and The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China |
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| Abstract: | Objective To optimize the extraction technology of Lianqin Jiedu granules. Methods The transfer rate of berberine hydrochloride and baicalin rate as indexes, combined with single factor and orthogonal test method, the extraction process of Qinlian Jiedu granule was optimized. Results The optimal extraction process was 60% ethanol immersion 1.0 h, reflux extraction 2 times, the first time 1.5 h, 1:10 (g:mL), second time 1 h, 1:8 (g:mL). Conclusion The optimized extraction technology is stable and feasible, provide experimental basis for industrial production of Lianqin Jiedu granules. |
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| Keywords: | Lianqin Jiedu granule orthogonal test extraction process berberine baicalin |
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