| Effect of Astragalus polysaccharides on Erythrocyte Immune Adherence of Chickens Inoculated with Infectious Bursal Disease Virus |
| |
| 作者姓名： | LI Hong-quan Lloyd Reeve-Johnson WANGJun-dong |
| |
| 作者单位： | [1]College of Veterinary Medicine and Animal Science, Shanxi Agricultural University, Taigu 030801, P.R.China [2]Schools of Veterinary Science, Seddon Buildings, University of Queensland, Brisbane QLD 4072, Australia |
| |
| 摘 要： | Two hundred and forty specific pathogen free leghorn chickens were randomly divided into four groups and reared in isolated pens. The tested chickens were negative to infectious bursal disease virus （IBDV） at 25 d old. Group 1 was treated with saline, whereas Groups 2, 3, and 4 were inoculated with 0.3 mL IBDV suspension intranasally the next day. Groups 3 and 4 were also administered with Astragalus polysaccharides （APS） intramuscularly twice daily at 5 or 10 mg kg-1 BW, respectively, until 31 d old. The erythrocyte-C3b receptor rosette rate （E-C3bRR） and the erythrocyte-C3b immune complex rosette rate （E-ICRR） were measured at 25, 29, 32, 35, and 38 d old. The results showed that IBDV significantly reduced E-C3bRR and E-ICRR when compared with the control group （P 〈 0.05）, while simultaneous administration of APS with 1BDV maintained E-C3bRR at similar levels to the control group （P 〉 0.05） and increased E-ICRR when compared with the control group and the group non-treated with APS （P 〈 0.05）. APS treatment reduced the morbidity and mortality of chickens inoculated with IBDV （P 〈 0.05）. The results suggest that APS may enhance the immune adherence of chickens erythrocytes by affecting the activity and/or the number of complement receptors on the erythrocyte membrane. These findings can be beneficial in providing an understanding of the basic mechanisms required for the rational application of APS in modern medicine.
|
| 关 键 词： | 紫云英属多糖 鸡 传染性囊状病毒 血红球 中草药治疗 |
| 收稿时间： | 13 April 2007 |
Effect of Astragalus polysaccharides on Erythrocyte Immune Adherence of Chickens Inoculated with Infectious Bursal Disease Virus |
| |
| LI Hong-quan Lloyd Reeve-Johnson WANGJun-dong.Effect of Astragalus polysaccharides on Erythrocyte Immune Adherence of Chickens Inoculated with Infectious Bursal Disease Virus[J].Agricultural Sciences in China,2007,6(11):1402-1408. |
| |
| Authors: | LI Hong-quan Lloyd Reeve-Johnson WANG Jun-dong |
| |
| Institution: | 1. College of Veterinary Medicine and Animal Science, Shanxi Agricultural University, Taigu 030801, P.R.China;2. Schools of Veterinary Science, Seddon Buildings, University of Queensland, Brisbane QLD 4072, Australia;1. Department of Environmental Science, College of Resources and Environmental Science, East China Normal University, Dongchuan Road 500, Shanghai 200241, PR China;2. CAS Key Laboratory of Genome Sciences and Information, Beijing Key Laboratory of Genome and Precision Medicine Technologies, Beijing Institute of Genomics, Chinese Academy of Sciences, Beichen West Road 1, Beijing 100101, PR China;3. Department of Biology, College of Life and Environmental Science, Shanghai Normal University, Shanghai 200234, PR China;1. Biological Faculty, Moscow State University, Vorobyevi Gory, 119992, Moscow, Russia;2. Molecular Plant Biology, Department of Biochemistry and Food Chemistry, University of Turku, FI-20014, Turku, Finland;3. Institute of Basic Biological Problems RAS, Pushchino, Moscow Reg., 142290, Russia;4. Institute of Crystallography, National Research Council, Monterotondo, Italy |
| |
| Abstract: | Two hundred and forty specific pathogen free leghorn chickens were randomly divided into four groups and reared in isolated pens. The tested chickens were negative to infectious bursal disease virus (IBDV) at 25 d old. Group 1 was treated with saline, whereas Groups 2, 3, and 4 were inoculated with 0.3 mL IBDV suspension intranasally the next day.Groups 3 and 4 were also administered with Astragalus polysaccharides (APS) intramuscularly twice daily at 5 or 10 mg kg-1 BW, respectively, until 31 d old. The erythrocyte-C3b receptor rosette rate (E-C3bRR) and the erythrocyte-C3b immune complex rosette rate (E-ICRR) were measured at 25, 29, 32, 35, and 38 d old. The results showed that IBDV significantly reduced E-C3bRR and E-ICRR when compared with the control group (P ＜ 0.05), while simultaneous administration of APS with IBDV maintained E-C3bRR at similar levels to the control group (P＞ 0.05) and increased E-ICRR when compared with the control group and the group non-treated with APS (P ＜ 0.05). APS treatment reduced the morbidity and mortality of chickens inoculated with IBDV (P ＜ 0.05). The results suggest that APS may enhance the immune adherence of chickens erythrocytes by affecting the activity and/or the number of complement receptors on the erythrocyte membrane. These findings can be beneficial in providing an understanding of the basic mechanisms required for the rational application of APS in modern medicine. |
| |
| Keywords: | Astragalus polysaccharides chicken infectious bursal disease virus (IBDV) erythrocyte immune modulation herbal therapy |
| 本文献已被 维普 万方数据 ScienceDirect 等数据库收录！ |
|
