肉仔鸡低血糖-尖峰死亡综合征的流行病学分析和病原初探

自2003年6月份以来，在我国北方肉鸡饲养基地普遍流行了一种主要侵害肉仔鸡的疾病，低血糖-尖峰死亡综合征(HSMS)。HSMS发病日龄集中于10～18日龄．临床表现为突然出现的高死亡率，病鸡头部震颤、运动失调、昏迷、失明、死亡。先后对黑龙江、吉林、辽宁、内蒙古、天津、河北、山东等省进行调查．发现HSMS在这几个省的很多肉鸡饲养区广泛存在。对发生该病的259个肉鸡饲养户的调查结果显示．该病与祖代种鸡没有关系．病原可能来自受污染的父母代种鸡场。平均发病率为17．9％。发病鸡群血糖浓度极显著的下降。从2个发病鸡群的病鸡肠道内容物中观察到病毒颗粒．病毒呈多形性．有囊膜，直径约80-100nm，表面有棒状纤突，长约10-20nm．与冠状病毒类似。

Preliminary Studies on the Pathological Agent and Epidemiological Analysis of Hypoglycemia Spiking Mortality Syndrome

A new fatal disease, hypoglycemia spiking mortality syndrome(HSMS), affected primarily the broiler chickens has been found to be prevalent in north China since last June. The broiler chickens of 10 to 18 days-old are most sensitive, and the clinical manifestations are head tremors , movement disorder ,recumbancy , loss of sight and death. An epidemiological investigation was carried out in the provinces of Heilongjiang , Jilin, Liaoning, Innermongolia, Tianjing, Hebei and Shandong. It was found that HSMS exists extensively in these regions .The results from 259 broiler farms showed that the disease are not occurring in the grandparental breeding farms, and we assumed the disease originated from the contaminated parental breeding farms . The mean morbidity was 17.9% , the blood glucose concentration of the affected chickens decreased significantly. The viral particles were observed in the intestine content samples from the infected chickens in two infected farms. The viral particles appear multi-shaped with diameter of about 80 to 100 nm, enveloped with stick -like spikes about 10 to20nm. The morphology of the viral particles seem like coronavirus.