Gonadotropins and their paracrine signaling network in
the zebrafish ovary |
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Authors: | Wei Ge |
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Institution: | (1) Department of Biology, The Chinese University of Hong Kong, Shatin, Hong Kong, New Territories, China |
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Abstract: | Pituitary gonadotropins, follicle-stimulating hormone (FSH) and luteinizing hormone (LH), play fundamental roles in vertebrate
ovarian development and function. However, there has been an increasing body of evidence that the actions of FSH and LH are
mediated or modulated by a variety of locally produced peptide or protein factors, which form an intimate regulatory network
within and between the ovarian follicles. In the past few years, a variety of growth factors have been identified and characterized
in the zebrafish ovary including activin and epidermal growth factor (EGF), which are important components of the intraovarian
communication network. To understand how this local network interacts with the gonadotropins from the pituitary, we have recently
cloned and characterized all the subunits of zebrafish FSH and LH from the pituitary as well as their receptors (FSHR and
LHR) from the ovary. Using the Chinese hamster ovary (CHO) cells as the bioreactor, we have produced recombinant zebrafish
FSH and LH with biological activities. With the recombinant hormones available, the functions of zebrafish FSH and LH in the
ovary and their interactions with the local factors will be an important issue to address in the future. This review briefly
summarizes some recent work from our laboratory and others on both gonadotropins and their potential intraovarian signaling
factors in the zebrafish. |
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Keywords: | FSH LH FSHR LHR Activin EGF Ovary Zebrafish |
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