低温游泳结合银杏叶提取物给药对高脂血症大鼠血脂代谢的影响

目的]研究低温游泳运动结合银杏叶提取物（GBE）给药对高脂血症大鼠血脂代谢的影响。方法]通过高脂饲料喂养大鼠模型试验42 d,获高脂血症试验鼠,将大鼠随机分成4组（n=3）,分别为对照组、安静药物组、单纯低温游泳运动和低温游泳结合GBE给药组,测定各组大鼠血清总胆固醇（TC）、甘油三酯（TG）和高密度脂蛋白-胆固醇（HDL-C）含量,同时测定血清、肝脏、心脏组织中过氧化脂质（LPO）及超氧化物歧化酶（SOD）活性。结果]各试验组均能降低肝脏指数,SOD活性也明显降低;低温游泳联合GBE组能明显降低大鼠血清TC、TG值。结论]低温游泳联合GBE给药可以调节高血脂大鼠血脂代谢,明显降低血液总胆固醇和甘油三酯,有助于高脂血症的改善。

Effects of Swimming in Cold Water Combined with GBE on Serum Lipid Metabolism of HLP Rats

Objective] To observe the influence of swimming in cold water coupled with GBE on serum lipids metabolism.Method] Reared with high fat forage for forty-two days,the hyperlipidemia rats were obtained and subdivided into four groups randomly(N=3) including control group,GBE group,swimming in cold water group and swimming in cold water combined with GBE group.Contents of cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL-C) and the activity of SOD and LPO in serum,liver and heart of rats in each group were determined by enzyme method.Result] The liver indices and SOD activity were lowered in all groups;the contents of TC and TG in serum of rats in swimming in cold water combined with GBE group were lowered markedly.Conclusion]Swimming in cold water combined with GBE can regulate serum lipid metabolism in hyperlipidemic rats by lowering TC and TG in serum markedly,which can help to improve hyperlipidemia.