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SHI Yingzi MA Guangpeng WU Xiangjin JIANG Ling WANG Xiangjing* and BAI Hua College of Life Sciences Northeast Agricultural University Harbin China China Rural Technology Development Center Beijing China Zhejiang Hisun Pharmaceutical Co. Ltd. Taizhou Zhejiang China 《东北农业大学学报(英文版)》2007,14(4):310-313
In order to screen a high-yield spergualin-production strain and an optimal fermentation medium,large numbers of isolates were selected after ultraviolet(UV)mutation and self-tolerant mutation of Bacillus laterosporus A7.A high-yield strain A-94-7 was obtained and the spergualin productivity was 4.1-fold of the parent strain.The genetic stability of the high-yield strain Bacillus laterosporus A-94-7 was very good.After fermentation medium optimization,Bacillus laterosporus A-94-7 was able to produce 380 mg?L-1.The spergualin productivity in Bacillus laterosporus A7 was increased 4.75-fold by mutation and medium optimization. 相似文献
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