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1.
The present study was aimed to investigate the possible interaction of the standardized extract of Acorus calamus (AC) with Cytochrome P450 enzyme, quantitative determination of the α-asarone in the AC rhizome was performed by RP-HPLC method. In vitro interaction of the plant extract was evaluated by CYP450-carbon monoxide complex (CYP450-CO) assay. Effect on individual isoforms such as CYP3A4 and CYP2D6 isozymes were analyzed through fluorescence product formation and respective IC50 values were determined. CYP450-CO assay showed moderate interaction potential. Extract showed higher IC50 values (46.84 ± 1.83-32.99 ± 2.21 μg/ml) comparing to the standard inhibitors and lower IC50 value than α-asarone (65.16 ± 2.37-42.15 ± 2.45 μg/ml). 相似文献
2.
Ethanolic extract of Rungia repens aerials parts (300 and 600 mg/kg p.o) showed diuretic activity in rats. The acute toxicity, orally evaluated in mice, was found to be higher than 3000 mg/kg. 相似文献
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Ranendra Kumar Majumdar Binaya Bhusan Nayak Subrata Basu 《Journal Of Aquatic Food Product Technology》2013,22(4):423-440
ABSTRACT “Lona ilish” is a salt fermented fish product prepared exclusively from fatty Indian shad (Tenualosa ilisha). Despite the presence of salt and metals coming from the container used for fermentation, rancidity is not observed as long as the products are kept immersed in the fermenting brine. To understand the technical principles of this indigenous preservation method, the traditional preparation was followed along with analyses of chemical and microbiological changes. The biochemical and microbiological changes were followed at 15 day intervals during the fermentation period of 150 days. From the 45th day of fermentation onwards, the microbial flora in the product was composed of only two species, tentatively identified as Bacillus licheniformis and Micrococcus kristinae. Because Bacillus licheniformis showed some atypical biochemical reactions, it was tentatively identified as Bacillus licheniformis var. III. These two bacterial species either singly or collectively were involved in the fermentation process. 相似文献
6.
Madonna T. Thachil Basu Subrato Mithlesh K. Chouksey 《Journal Of Aquatic Food Product Technology》2013,22(1):46-64
ABSTRACTExtrusion cooking plays an important role in the production of puffed snacks, which enjoy wide acceptance all over the world and are potential vehicles for increasing the consumption of n-3 fatty acids. Response surface methodology (RSM) with central composite design was adopted to investigate the effects of four independent variables (fish powder, fish oil, moisture, and screw speed) at five levels on expansion ratio, breaking strength index, hardness, color, and thiobarbituric acid reactive substances (TBARS). A second order polynomial model was used to study the main, interactive, and quadratic effects of the independent variables and to explain the relationship between the responses and independent variables. Moisture was found to be the most significant factor (p < 0.001) influencing expansion ratio, breaking strength index, and color. Inclusion of fish powder and fish oil were found to be negatively associated with the expansion characteristics, resulting in decreased lipid oxidation due to less exposed surface area of the extrudates to air. Further, the absence of linear effect of fish powder and fish oil on TBARS demonstrated the possibility to incorporate higher levels of these ingredients to produce oxidatively stable extruded snacks rich in fish proteins. 相似文献
7.
Most fenugreek, Trigonella foenum-graecum L. suitable for western Canada exhibit an indeterminate growth habit and take about 120 days to produce a good proportion
of high quality seed. Late maturity is a major inconvenience for seed producers in temperate climates prevalent in this region
where plants must mature within a much shorter growing season. The objective of this study was to develop early maturing fenugreek
mutants with a determinate growth habit to ensure uniform maturity within the 100 frost free days available on the Canadian
prairies. Seeds from Tristar Fenugreek, a forage cultivar developed for production in western Canada, were treated with 10–300 mM
ethyl methane sulfonate (EMS) for 2–24 h and plants were selected for determinate growth habit, early maturity and high seed
yield. This mutation breeding approach has detected new breeding material exhibiting early seed maturity coupled with high
seed yield, seed quality and determinate growth habit. Successful development of useful mutants in fenugreek was reported
before, but this is the first report on successful use of mutation breeding for improvement in quantitative traits in this
crop. 相似文献
8.
Mid-storage hydration-dehydration treatments with medium-vigour lettuce seed very effectively reduced physiological deterioration in storage and ultimately showed better field emergence and final yield. Soaking-drying treatment of high-vigour lettuce seed was not effective. Pre-sowing treatment of medium-vigour lettuce seed, though less effective than mid-storage treatment, gave better field performance, but high-vigour seed did not benefit from the treatment. For carrot, both mid-storage and pre-sowing seed treatments proved beneficial, with the former showing better performance than the latter. Unlike lettuce, well-preserved carrot seed responded positively to the pre-sowing treatment. 相似文献
9.
Samit Kumar Nandi Biswanath Kundu Samir Kumar Ghosh Dipak Kumar De Debabrata Basu 《Journal of veterinary science (Suw?n-si, Korea)》2008,9(2):183-191
The present study was undertaken to evaluate porous hydroxyapatite (HAp), the powder of which was prepared by a novel aqueous solution combustion technique, as a bone substitute in healing bone defects in vivo, as assessed by radiologic and histopathologic methods, oxytetracycline labeling, and angiogenic features in Bengal goat. Bone defects were created in the diaphysis of the radius and either not filled (group I) or filled with a HAp strut (group II). The radiologic study in group II showed the presence of unabsorbed implants which acted as a scaffold for new bone growth across the defect, and the quality of healing of the bone defect was almost indistinguishable from the control group, in which the defect was more or less similar, although the newly formed bony tissue was more organized when HAp was used. Histologic methods showed complete normal ossification with development of Haversian canals and well-defined osteoblasts at the periphery in group II, whereas the control group had moderate fibro-collagenization and an adequate amount of marrow material, fat cells, and blood vessels. An oxytetracycline labeling study showed moderate activity of new bone formation with crossing-over of new bone trabeculae along with the presence of resorption cavities in group II, whereas in the control group, the process of new bone formation was active from both ends and the defect site appeared as a homogenous non-fluoroscent area. Angiograms of the animals in the control group showed uniform angiogenesis in the defect site with establishment of trans-transplant angiogenesis, whereas in group II there was complete trans-transplant shunting of blood vessel communication. Porous HAp ceramic prepared by an aqueous combustion technique promoted bone formation over the defect, confirming their biologic osteoconductive property. 相似文献
10.
Mythily SubramaneyaanSachin Rustagi Sambit N. BhattacharyaAsok K. Tripathi Basu D. BanerjeeRafat S. Ahmed 《Pesticide biochemistry and physiology》2012,102(1):91-94
The scabicide, lindane induces oxidative stress and immunological alterations. The present study was undertaken to assess the ameliorative effects of antioxidant supplementation in lindane treated scabies patients. Scabies patients were treated with either 1% lindane or 1% lindane along with antioxidant (Lycored or Vitamin-E). Oxidative stress and immunological parameters were evaluated in blood samples and compared with healthy controls. Lindane caused a significant increase in malonedialdehyde (MDA) levels and decrease in reduced glutathione (GSH) and ferric reducing ability of plasma (FRAP), which was attenuated by anti-oxidant therapy. The IL-1α levels were significantly enhanced in scabies patients per se and remained unaffected after lindane/anti-oxidant treatment. The TNF-α and nitroblue tetrazolium (NBT) reduction levels were not significantly different in all the groups. Topical application of lindane induces significant free radical generation and may cause immunological alterations which can be reversed by antioxidant therapy. 相似文献