Sequence variants in SLITRK1 are associated with Tourette's syndrome

Tourette's syndrome (TS) is a genetically influenced developmental neuropsychiatric disorder characterized by chronic vocal and motor tics. We studied Slit and Trk-like 1 (SLITRK1) as a candidate gene on chromosome 13q31.1 because of its proximity to a de novo chromosomal inversion in a child with TS. Among 174 unrelated probands, we identified a frameshift mutation and two independent occurrences of the identical variant in the binding site for microRNA hsa-miR-189. These variants were absent from 3600 control chromosomes. SLITRK1 mRNA and hsa-miR-189 showed an overlapping expression pattern in brain regions previously implicated in TS. Wild-type SLITRK1, but not the frameshift mutant, enhanced dendritic growth in primary neuronal cultures. Collectively, these findings support the association of rare SLITRK1 sequence variants with TS.     

Calcium, nutrient and food intake of Greek Orthodox Christian monks during a fasting and non-fasting week

OBJECTIVE: To assess the Ca, nutrient and food intake of Greek Orthodox Christian monks during a vegetarian-type fasting week, compared with their normal diet. DESIGN: Dietary data collection (using 7 d weighed food records), anthropometric and blood pressure measurements, as well as serum glucose and lipid analyses, were performed during Palm Sunday week (fasting) and the week following Pentecost Sunday (non-fasting). Mean daily nutrient and food (g/d) intakes were calculated from the food records. SETTING: The study took place in two monasteries in the Municipality of Heraklion, Crete. SUBJECTS: The study involved ten healthy monks aged 254 (sd 10June 2005. RESULTS: Nutrient and food intake profiles were more favourable during the fasting week, when participants had lower intakes of total and saturated fat and trans-fatty acids, and higher intakes of dietary fibre, Fe, folate, legumes and fish/seafood. Ca intake was lower when participants fasted, whereas consumption of dairy products, meat and eggs increased significantly in the non-fasting week. Systolic blood pressure was significantly higher, whereas blood lipid levels were more favourable during the fasting week. CONCLUSIONS: The periodic vegetarianism recommended by the Greek Orthodox Church contributes to the favourable profiles of several biomarkers of health among this sample of monks. The fasting rituals described are an important component of the traditional diet of Crete and should be emphasised in nutrition education programmes promoting this Mediterranean eating pattern.     

Olive groves: ``The life and identity of the Mediterranean'

Olive tree cultivation in theMediterranean goes back to ancient times. Evensince the Roman Age, olive cultivation spreadto the entire Mediterranean basin. Thislongevous tree integrates and identifieseconomically, socially, and culturally theinhabitants of this basin and determines itsrural landscape. For the residents of theMediterranean, olive oil constituted the mainsource of nutritional fats, their most valuableexport product, and was identified with theirculture. Even now, olive cultivation has amultiple importance for the Mediterranean. Theolive groves, which grow mostly on inclined,shallow, and low fertility soils, and onhand-made stone terraces, have limited wateringrequirements and sustain the fragile naturalresources of the Mediterranean. Today,olive cultivation in the Mediterranean is anadditional income source and supports thepopulation in rural areas during the winterperiod, which profit from summer and seatourism activity. Although anagro-ecosystem, the olive grove resembles thenatural Mediterranean ecosystem and abandonmenttransforms them into natural Mediterranean typeforests. Their change of use from olivecultivation to pasture degrades the ecosystemand decreases the natural resources, because ofover-grazing. At this time, two major factorsthreaten the traditional olive cultivation (i)the competition of the intensive olive grovesin plain and irrigated areas and (ii) thecheaper seed-oils, which intensify theabandonment of traditional olive groves andchange them into pasture, resulting in thedeterioration of the ecosystem. Olivecultivation has left its mark on life in theMediterranean and has contributed to thesustainability of natural resources.Nevertheless, it succumbs under the pressure ofcurrent socioeconomic situations. Today, theconservation of olives in productionconstitutes a necessity for the fragileMediterranean ecosystems and a challenge foreverybody involved.     

Future directions in the European union for veterinary education as related to food-producing animals, with special reference to Greece

During the past 50 years, procedures for raising food-producing animals have changed. Intensification of food production was necessary to keep prices low and to fulfill market demands for the continuously increasing worldwide population. Intensification of farming procedures produced many new problems, some of which had a considerable impact on public opinion about how animals are raised and how food of animal origin is produced and preserved. "Man made diseases" of animals such as bovine spongiform encephalopathy (BSE); contamination of foods with dioxins either through contamination of animal feeds or from the environment; and increased microbial resistance to drugs used for treatment, for prophylaxis of animals from infectious agents, and for growth promotion are some well-known hazards of intensified farming. Veterinarians working on food-producing animals are faced with an increased demand for foods of high quality and safety in developed countries, and higher quantities in the rest of the world. These qualitative and quantitative changes indicate that they must adjust to these new conditions. They will be most successful if their education is adjusted to meet the challenges that the public has created for them through new concepts of the production of food of animal origin. One such concept is the production of foods under fully certified procedures from the farm to the consumer's table. Food safety measures protecting public health will better be achieved if the education of the future veterinarian includes the principles of Hazard Analysis Critical Control Points (HACCP) starting at farm level. This article provides some market-driven ideas in this direction for European Union (EU) countries, including Greece.     

Defining critical habitat conditions for the conservation of three endemic and endangered cyprinids in a Mediterranean intermittent river before the onset of drought

相似文献