A Blinded Comparison of the Efficacy of Daily and Twice Daily Trimethoprim-Sulfadiazine and Daily Sulfadimethoxine-Ormetoprim Therapy in the Treatment of Canine Pyoderma

Abstract— In a blinded trial to determine the efficacy of potentiated sulfa drugs in the treatment of canine pyoderma, 50 dogs with superficial pyoderma were randomly assigned to receive either once or twice daily trimethoprim-sulfadiazine (30mg.kg^-1) or once daily sulfadimethoxine-ormetoprim (55mg.kg^-1 on the first day, then 27.5 mg.kg^-1 thereafter). Dogs were evaluated prior to antibiotic therapy. Clinical efficacy of the antibiotic was assessed after 3 weeks of antibiotic therapy and, if needed, after 6 weeks of antibiotic therapy. Forty-five dogs completed the study; 43 dogs were used in the statistical analysis. The percentage of dogs that were cured of their pyoderma with once daily trimethoprim-sulfadiazine was 38.5% by 3 weeks and 75.9% by 6 weeks. With twice daily trimethoprim-sulfadiazine, 57.1 and 78.6% of dogs were cured by 3 and 6 weeks, respectively. With once daily sulfadimethoxine-ormetoprim, 75.0 and 100% of dogs were cured by 3 and 6 weeks, respectively. This difference was not statistically significant, possibly due to the low sample size. Few adverse effects were noted. Résumé— Dans une étude en double aveugle pour apprécier l'efficacité des sulfamides potentialisés dans le traitement des pyodermites canines, cinquante chiens présentant une pyodermite superficielle ont reçu, au hasard, soit deux fois ou une fois par jour du triméthoprime-sulfadiazine (30 mg.kg^-1) ou une fois par jour du sulfadiméthoxine-ormétoprime (55mg.kg^-1 le premier jour, puis 27.5 mg.kg^-1). Les chiens ont étéévalués avant le traitement. L'efficacité clinique de l'antibiotique a été appréciée après 3 semaines de traitement et, si besion est, après 6 semaines. Le pourcentage de chiens guéris avec une prise quotidienne de triméthoprime-sulfadiazine était de 33.5%à 3 semaines et 75.9%à 6 semaines. Avec des prises biquotidiennes de triméthoprime-sulfadiazine 57.1% et 78.6% des chiens étaint guéris à 3 et 6 semaines. Avec une prise quotidienne de sulfadiméthoxine-ormétoprime, 75.0% et 100.0% des chiens étaient guéris à 3 et 6 semaines. Cette différence n'était pais statistiquement significative, probablement à cause de la taille trop faible de l'échantilon. Très peu d'effects secondaires ont été notés. Zusammenfassung— Für eine Blindstudie zur Bestimmung der Wirksamkeit von potenzierten Sulfonamidpräparaten bei der Behandlung kaniner Pyrodermie wurden 50 Hunde mit oberflächlicher Pyodermie zufällig ausgewählt, um entweder einmal oder zweimal täglich Trimethoprim-Sulfadiazin (30mg/kg) oder einmal täglich Sulfadimethoxin-Ormetoprim zu erhalten (55 mg/kg am ersten Tag, danach 27,5 mg/kg). Die Hunde wurden vor der antibotischen Therapie untersucht. Die klinische Wirksamkeit der Antibiose wurde nach 3 Wochen antibiotischer Therapie und, wenn nötig, nach 6 Wochen antibiotischer Therapie ausgewertet. 45 Hunde durchliefen die Studie vollständig; 43 Hunde fanden in die statistische Analyse Eingang. Der Prozentsatz der Hunde, deren Pyrodermie durch einmal tägliches Trimethoprim-Sulfadiazin geheilt wurde, lag bei 38,5% nach 3 Wochen und bei 75,9% nach 6 Wochen. Bei zweimaliger Trimethoprim-Sulfadiazin-Verabreichung wurden 57,1% und 78,6% der Hunde nach 3 bzw. 6 Wochen geheilt. Mit einer einmal täglichen Verabreichung von. Sulfadimethoxin-Ormetoprim wurden 75,0% und 100% der Hunde nach 3 bzw. 6 Wochen geheilt. Dieser Unterschied war statistisch nicht signifikant, möglicherweise aufgrund der geringen Fallzahlen. Es wurden nur wenige Nebenwirkungen festgestellt. Resumen A cincuenta perros que presentaban pioderma superficial se les evaluó para la eficacia de antibioticos potenciados de tipo sulfamídico en el tratamiento del pioderma canino, por medio de la administración de una a dos veces diarias de trimetoprim-sulfadiazina (30 mg/kg), o sulfadimetoxinaormetoprim una vez al día (55 mg/kg en al primer día, y 27.5 mg/kg después de la primera dosis). Los animales se examinaron antes del tratamiento con antibióticos. La eficacia clínica del tratamiento se evaluó a las tres o seis semanas en los casos necesarios. Cuarenta y cinco de los perros completaron el estudio; 43 se utilizaron en analisis estadísticos. El porcentaje de perros curados con el tratamiento diario a base de trimetoprim-sulfadiazina fué del 38.5% a las 3 semanas, y 75.9% a las 6 semanas. De los animales tratados dos veces al día con trimetoprim-sulfadiazina, el porcentaje de cura fue del 57.1% y 78.6%, a las 3 y 6 semanas respectivamente. Con el tratamiento a base de sulfadimetoxina-ormetoprim una vez al día, 75.0% y 100% de los perros fueron curados a las tres y seis semanas. La diferencia no se encontró estadísticamente significativa, posiblemente debido al reducido número de perros evaluados. Se observaron posas reacciones adversas a la medicación.     

Comparison of ultrasonographic findings with clinical activity index (CIBDAI) and diagnosis in dogs with chronic enteropathies.

Intestinal wall thickness is neither a specific nor sensitive ultrasound parameter for detecting intestinal inflammation. We hypothesize that mucosal echogenicity, lymphadenomegaly, and secondary findings of the gastrointestinal tract would be more sensitive and specific markers for detecting and differentiating causes of chronic inflammatory bowel disease in dogs. Fifty-six client-owned dogs with chronic diarrhea and 10 control dogs were examined with two-dimensional, gray-scale ultrasound (time 0, 4, and 10 weeks post therapy) and small intestinal mucosal biopsies were performed at the 0- and 4-week time points. The clinical activity was assessed at each time point using the canine inflammatory bowel disease activity index (CIBDAI). Fifty-one dogs had inflammatory infiltration of the duodenal mucosa and were divided into three groups, food-responsive disease, idiopathic inflammatory bowel disease, and protein-losing enteropathy, based on their response to the different treatments and histology. Two different patterns of increased echogenicity of the mucosa were detected: hyperechoic speckles and hyperechoic striations. A normal, hypoechoic bowel mucosa in dogs with chronic diarrhea had a sensitivity of 80% and a specificity of 81% for the diagnosis of food-responsive disease. Hyperechoic striations had a sensitivity of 75% and a specificity of 96% for dogs with protein-losing enteropathy. Hyperechoic speckles were non-specific for diagnosing inflammatory bowel disease. There was a significant relationship between ultrasound score and CIBDAI at t0, but not following therapy. Mucosal echogenicity may be a better parameter for detecting inflammatory bowel disease than bowel wall thickness in dogs with chronic diarrhea.     

Tetanus and Dog Bites

Abstract— All breeds of dogs bite. None of the breeds in this investigation in Sweden were found to be particularly dangerous. Dog bites should always be regarded as contaminated wounds and they should be treated accordingly. Although the risk of tetanus must be taken into consideration in all wounds, it is of no greater significance in dog bites.
Résumé— Les chiens de toutes races mordent. Une enquête poursuivie en Suède n'a pas permis de noter qu'une race soit plus dangereuse qu'une autre en cette matière. Les morsures de chiens doivent toujours être considérées comme des blessures infectées et traitées en conséquence. Bien que, pour toute blessure, on doive évoquer le risque de tétanos, ce risque n'est pas plus grand lors de morsures de chiens.
Zusammenfassung— Alle Hunderassen beissen. Keine der im Rahmen der vorliegenden Untersuchungen in Schweden angetroffenen Rassen war besonders gefährlich. Hundebisse sollten immer als kontaminierte Wunden angesehen und entsprechend behandelt werden. Die Möglichkeit eines Tetanus muss bei alien Wunden in Betracht gezogen werden, doch tritt er nach Hundebissen keineswegs öfter als nach anderen Verletzungen auf.     

EFFECT OF CONTRAST MEDIUM INJECTION DURATION ON PEAK ENHANCEMENT AND TIME TO PEAK ENHANCEMENT OF CANINE PULMONARY ARTERIES

Our goal was to investigate the effect of contrast medium injection duration on pulmonary artery peak enhancement and time to peak enhancement. Fourteen dogs were allocated into one of seven predefined weight categories, each category contained two dogs. Dogs in each weight category were assigned to group A or B. Animals in each group received a different contrast medium injection protocol. In group A, a fixed injection rate of 5 ml/s was used. In group B, the contrast injection rate was calculated as follows: flow rate=contrast volume/scan duration+10 s. Time to peak enhancement and peak enhancement of the main left and right pulmonary arteries were measured on single‐level, dynamic CT images for a fixed time of 30 s. Rank correlation (Spearman's) coefficients between injection duration and time to peak enhancement and between body weight and peak enhancement were calculated. For group A, there was a significant negative correlation between peak enhancement and weight (r=?0.94; P=0.005), while for group B, there was no significant correlation (r=?0.64 and P=0.18). There was a significant correlation between time to peak enhancement and injection duration in both groups (group A: r=0.99; P=0.006 and group B: r=0.85; P=0.02). In conclusion, injection duration is a key feature in a CT angiography injection protocol. A protocol with an injection duration adjusted to the scan duration seems to be particularly suitable for veterinary applications where a population with great weight variability is studied.     

A spatially explicit, individual-based model to assess the role of estuarine nurseries in the early life history of North Sea herring, Clupea harengus

Herring (Clupea harengus) enter and remain within North Sea estuaries during well‐defined periods of their early life history. The costs and benefits of the migrations between offshore spawning grounds and upper, low‐salinity zones of estuarine nurseries are identified using a dynamic state‐variable model, in which the fitness of an individual is maximized by selecting the most profitable habitat. Spatio‐temporal gradients in temperature, turbidity, food availability and predation risk simulate the environment. We modeled predation as a function of temperature, the optical properties of the ambient water, the time allocation of feeding and the abundance of whiting (Merlangius merlangus). Growth and metabolic costs were assessed using a bioenergetic model. Model runs using real input data for the Scheldt estuary (Belgium, The Netherlands) and the southern North Sea show that estuarine residence results in fitter individuals through a considerable increase in survival probability of age‐0 fish. Young herring pay for their migration into safer estuarine water by foregoing growth opportunities at sea. We suggest that temperature and, in particular, the time lag between estuarine and seawater temperatures, acts as a basic cue for herring to navigate in the heterogeneous space between the offshore spawning grounds at sea and the oligohaline nursery zone in estuaries.     

Papular and Plaque-like Mucinosis in a Puppy

Abstract— A case of a papular and plaque-like superficial dermal mucinosis with pruritus in a mixed-breed puppy is reported. The mucinosis and pruritus were non-responsive to glucocorticoid or antibiotic therapy and the dog was eventually euthanised at the owner's request. This type of mucinosis has not been reported in the dog to the authors' knowledge. It shares some similarities with discrete papular mucinosis and self-healing juvenile cutaneous mucinosis in people.
Résumé— Un cas de mucinose dermique superficielle en plaque et papuleuse avec prurit chez un chiot croisé est décrit. La mucinose et le prurit ne répondirent pas à l'antibiothérapie et à la corticothérapie et le chien fut finalement euthanasiéà la demande du propiétaire. Ce type de mucinose n'a jamais été décrit chez le chien à la connaissance de l'auteur.
Zusammenfassung— Ein Fall einer papulösen und plaque-ähnlichen oberflächlichen dermalen Muzinose mit Pruritus bei einem Mischlingswelpen wird beschrieban. Muzinose und Pruritus sprachen nicht auf die Behandlung mit Glucocorticoiden oder Antibiotika an, und der Hund wurde schließlích auf Wunsch des Besitzers euthanisiert. Diese Art der Muzinose wurde nach den Informationen des Autors beim Hund bislang nicht beschrieben.
Resumen  Se describe un caso de mucinosis dérmica superficial pruriginosa de tipo papular y con formación de pseudo placas en un cachorro mestizo. La mucinosis y el prurito no respondieron a la terapia con glucocorticoides ni a la terapia con antibiótico y el perro se eutanasió finalmente a petición de los propietarios. Este tipo de mucinosis no se había descrito previamente en el perro.