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排序方式: 共有136条查询结果,搜索用时 17 毫秒
1.
Since the first publication on “regional ileitis”, the relevance of this chronic inflammatory disease condition termed finally as Crohn's disease is continuously increasing. Although we are beginning to comprehend certain aspects of its pathogenesis, many facets remain unexplored. Host's gut microbiota is involved in a wide range of physiological and pathological processes including immune system development, and pathogen regulation. Further, the microbiome is thought to play a key role in Crohn's disease. The presence of Crohn's-associated variants of NOD2 and ATG16L genes appears to be associated not only with alterations of mucosal barrier functions, and bacterial killing, but the gut microbiota, as well, reflecting a potential relationship between the host's genotype and intestinal dysbiosis, involved in disease etiology. This review aims to characterize some exciting new aspect of Crohn's disease pathology, focusing mainly on the role of intestinal microbes, and their interplay with the immune system of the host. 相似文献
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Cristiano G. Pereira Alexandre L.N. Silva Patrícia de Castilhos Eneida C. Mastrantonio Richard A. Souza Raquel P. Romo Renata J. Rezende Janethe D.O. Pena Marcelo E. Beletti Maria A. Souza 《Veterinary parasitology》2009,165(3-4):231-240
The aim of this study was to evaluate the histopathological features in tissues of mice infected by human isolates (I, II, and III) or the reference M2903 strain of Leishmania braziliensis complex. BALB/c and C57Bl/6 mice were infected in the hind footpad with 106 stationary-phase promastigotes of L. braziliensis complex. The evolution of lesions was observed for 10 weeks and the animals were then euthanized and liver, spleen and popliteal lymph nodes were collected. Tissues were stained with hematoxylin and eosin and analyzed by immunohistochemistry assay. Increased thickness of infected footpads was observed in all animals, lesions were nodular and non-ulcerated. Mice infected with isolate I presented inflammatory infiltrates consisting predominantly of mononuclear cells in all tissues examined, and also a great number of megakaryocytes, compared with other isolates. Infection with isolate II led to an infected footpad enlargement not seen in other isolates. In addition, mononuclear infiltrates in the liver and hemosiderin in spleen were noted. Conversely, mice infected with either isolate III or M2903 strain only showed an increased number of megakaryocytes in spleen. All tissues examined had detectable amastigote forms of Leishmania by immunohistochemistry in all groups. Taking together, our results showed an unforeseen behavior of different isolates of L. braziliensis complex that led to diverse pathological findings. 相似文献
3.
Fabiana Dal Pozzo Claude Saegerman Etienne Thiry 《Veterinary journal (London, England : 1997)》2009,182(2):142-151
Bluetongue virus (BTV) is an arthropod-borne virus infecting domestic and wild ruminants. Infection in cattle is commonly asymptomatic and characterised by a long viraemia. Associated with the emergence and the recrudescence of BTV serotype 8 (BTV-8) in Northern and Central Europe, remarkable differences have been noticed in the transmission and in the clinical expression of the disease, with cattle showing clinical illness and reproductive disorders such as abortion, stillbirth and fetal abnormalities. Several investigations have already indicated the putative ability of the European BTV-8 strain to cross the bovine placenta and to cause congenital infections. The current epidemiological and pathological findings present an unusual picture of the disease in affected bovines. 相似文献
4.
鸡贫血因子病的血液病理学变化 总被引:1,自引:0,他引:1
本实验用鸡贫血病毒感染1日龄健康AA雏鸡,以未感染雏鸡为对照,在感染后7、14、28、35、42日龄检测其外周血液各种血细胞数量,血红蛋白含量,红细胞压积,红细胞平均体积,红细胞平均血红蛋白量、红细胞平均血红蛋白浓度;骨髓红系祖细胞、粒单系祖细胞(CUF-GM)、基质成纤维祖细胞(CFU-F)的增殖功能;血清因子和胞腺集落刺激因子(CSF)对造血祖细胞增殖功能的影响;骨髓造血细胞分化功能;骨髓造血 相似文献
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锦鲤暴发性出血症病原的研究 总被引:6,自引:0,他引:6
从患暴发性出症的锦鲤体内分离出2株细菌-052202和052203,应用细菌分离鉴定方法和法国Biomerieux FRC公司的API全自动微生物鉴定系统进行鉴定,结果显示:052202株为嗜麦芽窄食单胞菌(Stenotrophomonas maltophilia),052203株为温和气单胞(菌(Aeromonas sobria)。生物毒性试验的结果表明,温和气单胞菌可使健康锦鲤死亡,引起体表出血,肝,肾,脾,胆囊发生病变,有致病性;而嗜麦芽窄食单胞菌不引起健康锦鲤死亡,无致病性,28例药物的药敏试验结果表明,温和气单胞菌对新霉素,卡那霉素,庆大霉素,头孢噻吩,头孢曲松的头孢他啶的敏感性强或较强。 相似文献
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In order to characterize foot-and-mouth disease virus (FMDV) infection dynamics in pigs, two simulated-natural inoculation systems were developed and evaluated. Intra-oropharyngeal (IOP) and intra-nasopharyngeal (INP) inoculation both enabled precise control of dose and timing of inoculation while simulating field exposure conditions. 相似文献
10.
为验证小麦病程相关蛋白基因TαPR-1的功能,利用gus基因瞬间表达技术对基因枪法转化小麦幼胚的两个重要参数金粉用量和轰击距离进行了优化。研究结果表明,金粉用量为250.0μg.轰击距离9cm的轰击参数最为理想,GUS瞬间表达率和平均蓝点数分别可达89.8%和33.7个。采用此轰击参数.将TαPR-1基因导入扬麦158幼胚.经3~5mg/L Bialaphos筛选获得49株抗性再生植株.经PCR、Southern杂交分析.其中2株为阳性植株.转化率为0.11%。对转基因小麦植株进行苗期离体叶段和田间成株白粉病接种鉴定.初步结果表明,转基因植株对白粉病抗性与对照相比无明显差别。 相似文献