IL-33/ST2 axis in systemic lupus erythematosus in relation to chronic kidney injury and disease activity

AIM: To elucidate the association between chronic kidney injury and interleukin-33 (IL-33; an alarmin)/suppression of tumorigencity 2 (ST2) in patients with systemic lupus erythematosus (SLE).METHODS: Serum levels of IL-33 and soluble ST2 (sST2) were assessed by ELISA in 50 SLE patients and 30 healthy controls (HC).RESULTS: The levels of IL-33 and sST2, and IL-33/sST2 ratio were significantly higher in SLE patients than those in the HC. The IL-33 and sST2 levels were positively associated with SLE disease activity index (SLEDAI), erythrocyte sedimentation rate (ESR), proteinuria and triglyceride, but negatively associated with complement C3. IL-33/sST2 ratio was positively associated with SLEDAI and estimated glomerular filtration rate (eGFR). Independent explanatory variables associated with high IL-33/sST2 included chronic kidney disease (CKD) staging and albumin (R²=0.442), especially CKD staging.CONCLUSION: Elevated serum sST2 and IL-33 levels in SLE patients are correlated with disease activity and risk factors of kidney injury. IL-33/sST2 ratio may serve as a potential biomarker for chronic kidney injury in SLE patients.     

农民内源性增收推进农业现代化的困境与路径

分析了农民内源性增收推进农业现代化的困境,认为其根本障碍在于农业的先天弱质性、从农主体的素质滞后性和农业外在体制的缺陷性,在此基础上提出了相应的路径选择,即大力发展农业产业化、市场化和知识化。     

90年来中共历代中央领导集体政治交接简评

中国共产党成立90年来一共形成了四代成熟而稳定的中央领导集体。其中,第一、二代领导集体围绕最高领导权力的交接不甚成功,但从总体上讲,四代领导集体之间基本实现了正常的交接,并不断走向制度化。这是党自身能够健康发展,党领导的革命和建设事业兴旺发达的根本保证。     

努力提高农科院所党的建设科学化水平

该文结合中国农科院及其所属研究所党建工作的情况,按照提高党的建设科学化水平的新要求,以科学发展观为指导,深刻理解和正确把握党的建设的科学化内涵,进一步深化对党的建设和执政规律的认识。此外,该文联系实际,分析农科院所党建工作的新特点,找准党建工作着力点,坚持以人为本,加强组织建设,深化创先争优,构建和谐院所,充分发挥党组织的政治核心作用等方面提高党建工作的科学化水平。     

Utilization of Livestock''s Dejection as Biogas Origin in Building New Countryside in Heilongjiang Province--Developing Utilization of Biogas and Promoting Energy-saving and Emission Reduction

With the startup and execution of new socialistic countryside construction in Heilongjiang Province,the transition from castoff to resource is strengthened in the countryside,aiming at neat appearance of the countryside,clean production and saving energy.People produce biogas and provide the countryside with new energy by means of turning livestock's dejection into resources,composting of the plant and animal's leavings in the courtyard and even in the factory.It is helpful for the countryside to conserve t...     

超氧化物歧化酶模拟物对氧化应激IPEC-J2细胞抗氧化性能的影响

试验旨在探究在H₂O₂诱导的氧化应激状态下，超氧化物歧化酶模拟物（SODm）对仔猪空肠上皮细胞系（IPEC-J2）的保护作用。利用MTT法筛选出构建氧化应激模型H₂O₂的适宜浓度；将IPEC-J2细胞分别用0、0.05、0.5、5、50、500、2 000 U/mL SODm进行培养，利用MTT法分别在2、4、8、12 h时测定各组细胞存活率，筛选出SODm作用的适宜浓度和时间；根据构建的氧化应激模型和SODm适宜浓度和时间，将IPEC-J2细胞随机分为空白组、模型组、SODm处理组（SODm_0.5、SODm₅、SODm₅₀）和超氧化物歧化酶（SOD）处理组（SOD_0.5、SOD₅、SOD₅₀），分别测定各组细胞存活率、活性氧（ROS）含量及细胞内SOD、谷胱甘肽过氧化物酶（GSH-Px）活性及丙二醛（MDA）含量和总抗氧化能力（T-AOC）。结果表明：①H₂O₂构建细胞氧化应激模型的适宜浓度是1.0 mmol/mL。②当不同浓度SODm分别作用4、8、12 h时，0.5~50 U/mL SODm组细胞存活率显著高于空白组（P<0.05）；且8 h时存活率最高，在12 h时处于下降趋势。③除空白组外，SODm₅和SOD₅预处理的IPEC-J2存活率显著高于其他组（P<0.05）；且SODm和SOD组中细胞ROS含量显著低于模型组（P<0.05）；模型组与空白组相比，均显著降低了SOD、GSH-Px活性和T-AOC水平，提高了MDA含量（P<0.05）；与模型组相比，所有SODm和SOD处理组均显著提高了SOD、GSH-Px活性和T-AOC水平，降低了MDA含量（P<0.05），同时SODm₅₀组T-AOC水平显著低于SOD₅₀组（P<0.05）。综上，SODm对H₂O₂诱导氧化损伤状态下IPEC-J2具有保护作用。     

青海省海东市不同等级降水和旱涝关系研究

青海省海东市是青海省重要的粮食生产基地,干旱直接影响着农业的有序发展。利用1961—2015年青海省海东市5个气象站逐日降水资料,笔者分析各级雨量和雨日及Z指数的变化趋势,并研究各级雨量和雨日对旱涝的影响。结果表明：（1）夏（冬）半年降水以小雨（雪）和中雨（雪）为主;夏半年小雨和大到暴雨（中雨）的雨量及雨日呈减小（增加）趋势,冬半年各级雨量及雨日均呈减小趋势;（2）夏、冬半年Z指数均表现为不显著的减小趋势;（3）采用偏相关系数和相对贡献率分析,夏半年中雨和大到暴雨雨量及雨日对Z指数有显著的影响,冬半年小雪的雨量和雨日对Z指数变化影响最大;（4）采用合成分析法的标准化值,在偏涝年,各级雨量和雨日基本都为正值,夏半年差异主要表现在大到暴雨和中雨雨量和雨日,而冬半年差异主要表现在小雪雨量和雨日;在偏旱年,各级降水雨量和雨日基本都为负值,夏半年差异主要表现在中雨雨量和雨日,冬半年差异主要表现在小雪和中雪雨量和雨日。     

某高铁隧道小口径井抽水试验探讨

指出了在某高铁隧道勘察中采用小口径抽水试验方法,具有操作简单便捷,成本低的优势。通过小口径井抽水试验查明场地的水文地质条件,得出了水文地质原始数据资料,根据单孔稳定流承压水非完整井的水文地质实际情况,选取合适的公式分别计算出了隧道岩层渗透系数及影响半径,为高铁隧道的勘察设计及顺利施工提供参考。     

Asterosaponins: Structures,Taxonomic Distribution,Biogenesis and Biological Activities

Asterosaponins are a class of steroid oligoglycosides isolated from starfish with characteristic structures and diverse biological activities. In this review, we have attempted to combine the most important data concerning asterosaponins and give a list of these secondary metabolites with their structural peculiarities. The purpose of this review is to provide a brief but as complete as possible principal information about their chemical structures, taxonomic distribution in the marine environment, distribution in different geographical areas and depths, some properties, biological activities, and functions. Some other rare steroid metabolites from starfish, closely related in structures and probably biogenesis to asterosaponins, are also discussed.