Evaluation of transpulmonary ultrasound dilution cardiac output in piglets: accuracy,precision and trending ability with room temperature injectate

ObjectiveTranspulmonary ultrasound dilution (TPUD) is a minimally invasive technique to measure cardiac output (CO) using a 1 mL kg^–1 isotonic 37 °C saline injectate indicator. The objective was to evaluate the performance of TPUD using a room temperature saline injectate.Study designProspective experimental trial.AnimalsA total of seven anesthetized male Yorkshire piglets.MethodsPiglets aged 1 month and weighing 7.7–9.0 kg were anesthetized with detomidine–ketamine–hydromorphone–isoflurane and a pulmonary artery flow probe (PAFP) placed via a median sternotomy. The thoracic cavity remained open during measurement of CO by PAFP and TPUD. The TPUD indicators of 1 mL kg^–1 0.9% saline at 37 °C and 20 °C were compared during infusions of phenylephrine and dobutamine, blood withdrawal and replacement. Bias, limits of agreement (LoAs) and percentage error (PE) between each iteration of PAFP and TPUD were measured with Bland–Altman plots. Trending ability via concordance, angular bias and radial LoA were compared.ResultsBland–Altman plots showed negligible bias with varying LoAs. PEs of 22% and 38% were found for 37 °C and 20 °C saline injectates, respectively. In the four-quadrant plots, the concordance rate was 94% and 100% for measurements obtained with 37 °C and 20 °C saline injectates, respectively. Angular bias for both were < ±5 °, with radial LoA < ±7 °.ConclusionsTPUD was accurate when using 1 mL kg^–1 of isotonic saline at 37 °C in a range of CO within 0.2–0.8 L minute^–1, and it reliably tracked positive and negative changes in CO. Room temperature (20 °C) indicator was less accurate but equally able to track direction of changes in CO.Clinical relevanceThe use of room temperature injectates allows an easy, readily available clinical application of TPUD CO monitoring while preserving the trending ability of the monitor.     

新饲料添加剂N，O-羧甲基壳聚糖的急性毒性研究

【目的】研究N,O-羧甲基壳聚糖对鸡的急性毒性,评价该药的安全性;【方法】以最大浓度的N,O-羧甲基壳聚糖(10.5%),按20ml/(kg·bw)(2.1g/(kg·bw)/次)剂量24h内给鸡灌服;【结果】给药后连续观察7天,各组试验鸡全部存活,临床、剖检均未见到异常变化,测不出LD50,根据新药审批办法中关于急性毒性的要求,进行最大耐受量的测定。鸡灌服给予N,O-羧甲基壳聚糖的最大耐受量为10.5g/(kg·bw),相当于临床拟用量的3500倍;【结论】N,O-羧甲基壳聚糖毒副作用很小,临床可以安全应用。     

The Multiple Solutions for a Class of Quasilinear Elliptic Equations

A three critical point theorem is proved. As its applications, Dirichlet problem for a class of quasilinear elliptic equations cf second order is considered.     

THREE CRITICAL POINTS THEOREM AND ITS APPLICATIONS

In this paper, by use of the pseudo-gradient vector field, the three critical points theorem in [2] is extended to the C1 function in the Ba-nach space, and therefore the three critical, points theorem in [5] is strengthened and the existence of the saddle point of the C2 function is discussed.     

煤与瓦斯突出综合预测指标临界值的优化

为了提高煤与瓦斯突出预测的准确性、保障采掘工作面的安全、高效推进和降低防突工程成本,根据“三率”(预测突出率、突出预测准确率、不突出预测准确率)各自具有的合理区间属性和权重,以张集煤矿采掘工作面为例,采用区间数关联决策方法,得出综合预测指标 F ′的最优化区间为［370,380］;根据加权灰靶决策方法,得出预测指标临界值排序为400、390、380等;取最优化区间和排序靠前的临界值的交集,得到煤与瓦斯突出综合预测指标 F ′的临界值为380,并开展现场应用。结果表明,考虑评价指标的区间属性,并取预测指标区间与排序靠前的临界值的交集作为煤与瓦斯突出预测综合指标 F ′的最优临界值方法是合理的。     

射水抽气器最大吸气流量

为确定抽气器的工作范围,分析了单通道长喉管射水抽气器(即液气射流泵)在被吸气体为常压情况下最大吸气能力,认为喉管内液气两相混合的位置和流动状态是影响最大吸气流量的重要因素,喉管内发生两相临界流是有相变时抽气器的一种极限工况。采用一维流动公式计算了正常情况下最大吸气流量,试验数据说明在合理的抽气器尺寸情况下计算值与试验值一致。     

玉米不同生育期水分胁迫指标

采用田间小区实验 ,通过对玉米不同生育期、不同土壤水分条件下叶水势、气孔导度、光合作用、植株蒸腾、生理生态状况及产量形成的观测试验 ,并在总结已有成果的基础上 ,分析研究了玉米不同生育阶段的水分胁迫指标阈值 ,提出了玉米不同生育阶段的水分胁迫指标 ,为节水灌溉与灌溉管理提供了科学、实用的依据。     

立轴柱形变螺距螺旋开沟机临界转速分析

通过对螺旋开沟机所输土块的运动及受力情况进行分析可知：当土块与坑壁之间的摩擦力能阻止土块随叶片旋转时，土块在螺旋叶片上所受作用力相互平衡。由此，推导山立轴柱形变螺距螺旋开沟机的临界转速。此即为保证土壤在螺旋而上上升的基本条件，而实际转速则大于临界转速。该分析为进一步设计立轴柱形变螺距螺旋开沟机提供了依据。     

基于水盐生产函数的绿洲灌区水盐调控研究

土壤次生盐碱化是新疆灌溉农业所面临的最大环境问题。灌溉农业的快速扩展与灌排系统不完善是造成土壤次生盐碱化发生与恶化的关键因素。以水盐生产函数为依据,计算了不同生育阶段及全生育期阶段棉花相对产量与土壤全盐的关系,依据该计算结果对塔里木灌区的土壤盐化程度做了初步划分。基于塔里木灌区地下水埋深较浅且多为微咸水的事实,比较深入地探讨了地下水合理的动态水位及作物对潜水利用问题。最后,提出了灌区水盐调控的对策,强调排水系统的通畅运行是控制土壤次生盐碱化的关键,通过排水系统和减少灌溉定额使作物生长期的地下水埋深控制在1.6~2.1 m内,不但可以减少排水成本,而且也可使作物充分利用地下水,同时促进塔里木河水质的改善。