Safety and tolerability of 3-week and 6-month dosing of Deramaxx® (Deracoxib) chewable tablets in dogs

Although non-steroidal anti-inflammatory drugs (NSAIDs) are effective in reducing pain and inflammation, these agents have adverse effects. Selective inhibitors of COX-2 are an alternative to traditional NSAIDs. Deramaxx^® [Novartis Animal Health US, Inc. (NAH), Greensboro, NC, USA] contains the selective COX-2 inhibitor, deracoxib, and is approved for the relief of pain and inflammation associated with orthopedic surgery and osteoarthritis in dogs. The safety of Deramaxx was evaluated in two target animal safety studies: 40 dogs (four dogs/sex/group) received 0, 4, 6, 8, or 10 mg/kg/day deracoxib once daily for 21 days; and 60 dogs (five dogs/sex/group) received 0, 2, 4, 6, 8, or 10 mg/kg/day deracoxib once daily for 6 months. There was a dose-dependent trend towards increased blood urea nitrogen (BUN) in treated dogs, however mean BUN values remained within the reference range at the labeled doses. In both trials, histopathology revealed focal renal tubular degeneration/regeneration in some dogs receiving ≥6 mg/kg/day deracoxib. Focal renal papillary necrosis was seen in one dog treated with 8 mg/kg/day and in three dogs receiving 10 mg/kg/day deracoxib on the 6-month study. No other parameters of renal function were adversely affected for either study. Results show that Deramaxx is safe and well-tolerated in dogs when administered as directed.     

比较土壤和土壤－植物系统中由尿素转化的N2O的排放

A pot experiment with a sandy loam soil and spring wheat as test crop was conducted to compared the N2O emissio from soil system with plant cut off and from soil-plant syste with plant kept.The results showed that after urea fertilizer applied,the N2O emission from soil and soil-wheat system decreased exponentially with time,and its total amount was 0.34-0.63% and 0.33%-0.58% of applied urea-N respectively,no significant difference being found between these two systems.The N2O emission urea-N respectively,no significant difference being found between these two systems.The N2O emission had a very significant negative relationship (P=0.01) with the biomass of wheat plant.A combined application of urease inhibitor hydroquinone and nitrification inhibitor dicyandiamide could reduce the N2O emission by 50%-83% and 46-74%,respectively,from soil and soil-wheat system.The N2O was mainly produced and emitted from soil,and the soil biochemical regulation.i.e.applying related inhibitors into soil could effectively diminish the urea derived N2O emission.     

芸薹属作物抗病性基因同源位点上的遗传多样性

用已知的拟南芥抗病性基因的8对引物对60个芸薹属作物和1份拟南芥品系进行了遗传多样性 分析, 除GPA1, PR1外, 其他6对引物的同源片段都被检测到。 其中与Atloxl 1 , BGL2, RPS2及PG11四个基因同源的片段检出率较高, 分别为62.5%, 94.7%, 87.5% 及100%。 用这些同源片段估计了甘蓝型油菜抗耐菌核病材料中油821、 中R783、     

Potential use of Artemia biomass by‐products from Artemia cyst production for the nursing of goby Pseudapocryptes elongatus in Vietnam: effects on growth and feed utilization

The present study was performed to evaluate the effect of using Artemia biomass, by‐product from Artemia cyst production on growth and feed utilization of goby Pseudapocryptes elongatus fingerlings. A control diet containing fishmeal as main protein source was compared with four experimental diets in which fishmeal protein was replaced by increasing dietary levels of Artemia protein, namely 25%, 50%, 75% and 100%. The five test diets were compared with a commercial diet and dried Artemia. All diets were formulated to be equivalent in crude protein (360–370 g kg^?1) and lipid (58–65 g kg^?1). The experiment was conducted in 80 L plastic tanks filled with water at a salinity of 15 g L^?1. Goby fingerlings with 0.21 g initial weight were fed the test diets for 30 days. The results showed that weight gain and specific growth rate of goby were positively correlated with total feed intake. Moreover, growth performances and feed utilization in the fry receiving the commercial feed and fishmeal control diet were similar, both were inferior to the groups fed dried Artemia and the based formulated diets. These results illustrate that both dried Artemia and Artemia‐based feeds can be used for feeding goby fingerlings, indicating the high potential of using locally produced Artemia biomass, which could contribute to reduce the reliance on fishmeal and improve profits for Artemia producers.     

优质杂交粳稻新组合申优 27 的选育

对优质杂交粳稻新组合申优27的选育经过、产量表现、主要特征特性、栽培和制种技术进行了介绍。建立了杂交粳稻"双亲双优、抗性互补"育种技术,有效解决了优质和抗性的协调统一问题。