王先谦汉学研究与书院传播

王先谦是晚清一位重要的汉学大师。受道光以后晚来湖湘汉学之风和督学江南时江浙考据学派的影响 ,王先谦的治学呈现明显的汉学倾向 ;在湖湘理学传统和晚清经世思潮的影响下 ,王先谦的汉学又不同于传统的乾嘉汉学 ,已走出纯粹的考据而呈现出既趋重经史考据 ,又能调和汉宋、兼采古今、求实致用的多途取向。王先谦一生治学讲学 ,始终没有离开过书院。正是借由如南菁、思贤、城南、岳麓等书院 ,王先谦为传播汉学做出了重要贡献。     

Transplantation of human amnion epithelial cells improves learning and memory function in Alzheimer's disease-like pathology rat model

AIM: To observe the treatment effect and its immune regulation of human amnion epithelial cells (hAECs) on Alzheimer's disease (AD)-like pathology rat model. METHODS: The hAECs were isolated from amnion with trypsin digestion, and the phenotype of hAECs was analyzed by flow cytometry. SD rats (n=48) were randomly divided into sham control group, model group, medium group and hAECs group. AD-like pathology rat model was induced by bilateral intraventricular injection of lipopolysaccharide (LPS). hAECs (5×10⁵) were injected into the hippocampus of the AD-like pathology rats. At 2 weeks after transplantation, the animals were tested by Morris water maze to observe the function of learning and memory. The pathological change of the brain was observed by HE staining. The expression of amyloid β-protein 42(Aβ42) and Tau protein and the level of acetylcholine (ACh) in the injury brain were determined by immunohistochemistry. The survival and differentiation of hAECs in the hippocampus were measured by immunofluorescent technique. The percentages of lymphocyte subsets in the peripheral blood mononuclear cells were analyzed by flow cytometry. The contents of serum cytokines were detected by cytometric bead array. RESULTS: Compared with model group and medium group, hAECs group showed shortened escape latency (P<0.01), increased frequency of going through the platform (P<0.05), reduced loss of hippocampal neurons, decreased expression of Tau protein and Aβ42 in the hippocampus (P<0.05), increased ACh level in the hippocampus (P<0.05), decreased percentages of Th1 and Th17 subsets, increased percentages of Th2 and Treg cells (P<0.05), decreased concentrations of IFN-γ and IL-2 in the serum, and increased concentration of IL-4(P<0.05). CONCLUSION: hAECs improve the cognitive learning and memory function and alleviate pathologic damage of hippocampus through immune regulation in AD-like pathology rats.     

高校图书馆基于IC的知识管理与虚拟学习社区融合研究

知识管理与虚拟学习具有相关性与互补性,高校图书馆信息共享空间为知识管理与虚拟学习社区的融合创造了有利条件,因此知识管理与虚拟学习社区的融合是可行的,但是面临来自于观念、技术、功能、内容、交互性等方面的障碍。图书馆应尽可能地采用现代信息技术将知识管理系统与虚拟学习社区集成在一个IC内,进而提升自身的服务水平。     

湛江儿童公园景观设计

方案设计将以"儿童"为设计的主旨,配备与时俱进的功能和设施,丰富多彩的游乐场地,从本土特色海洋文化和传统中寻找设计灵感和元素,使得设计中更富有地域特色,帮助儿童认识和热爱家乡,从而打造极富特色并能够培养和锻炼孩子各方面能力,极具启发性、互动性、娱乐性的寓学于乐的儿童公园。     

浅议慕课及其对精品课程建设的启示

慕课(MOOC)在学习成本低、学习效率高、交互性强等方面受到了广大学习者的青睐,逐渐成为终身学习的一种渠道。精品课程建设是高校教育与教学改革工程必不可少的环节,精品课程建设第二期工程——精品资源共享课正在建设过程中。慕课运行方式对我国精品资源共享课建设具有一定借鉴意义。     

“一带一路”背景下农业类本科生外语素养的培养研究——基于项目式学习理论

随着“一带一路”倡议的不断推进,农学人才在逐渐加深的中国与沿线国家农业合作中的重要性日渐凸显。在此背景下,国家对农业类人才的要求也越来越高,仅掌握农业类专业技术的人才已不能很好地适应新时代的农业发展要求,英语素养成为农学人才的必备的语言能力。本文从提升农学本科生英语素养的重要性出发,分析目前农学本科生外语教学现状,并结合项目式学习理论探索提升农学本科生外语素养的途径,旨在为培养具有较高外语素养的应用型农学人才提供可行建议。     

金融时间序列指标判别框架：以特质波动率为例

基于拐点集合判别的TBUD方法主要思路是分析拐点集合间的关系，并在高维空间进行划分，从而搭建判别模型，并将分析框架应用在特质波动率等若干指标上，利用实证数据得到结论。应用TBUD判别框架可以发现，特质波动率等指标无法对拐点集合进行清晰划分，因而并不具有预测能力。     

五轴数控加工叶片无干涉刀位轨迹的计算

根据微分几何特性，提出五坐标数控加工叶片时对叶片的工作面和背面的刀位轨迹计算分开予以讨论，对工作面而言，利用平头立铣刀加工时不存在干涉，而对背面而言，可能存在干涉。根据干涉的种类，分别对全局干涉和局部刀具干涉提出了快速判定依据，并对干涉点进行了修正。指出利用Iso-scallop法可获得最优的轨迹和蔗，并给出了实例。