肥胖基因研究进展

与肥胖有关的基因已发现很多，但ob基因是研究的重点，其表达产物Leptin的作用机制已有较深入的了解。本文主要介绍了ob基因及其产物Leptin的作用机制、生物学效应、Leptin抵抗现象，以及其它与肥胖有关的基因和蛋白。     

瘦蛋白及其在动物繁殖中的研究进展

瘦蛋白(Leptin)是肥胖基因(ob基因)表达的蛋白质产物,主要产生于脂肪组织,向大脑反馈能量储存的信息并激活下丘脑中枢,调节进食和能量的消耗.此外,Leptin还可以通过直接或间接地影响下丘脑--垂体--性腺轴来调控动物的繁殖性能.笔者从Leptin的生物学基础、作用机理及繁殖调控等方面予以综述,并指出了其在家畜繁殖上的应用前景.     

瘦蛋白及其在动物繁殖中的研究进展

瘦蛋白（Leptin)是肥胖基因（ob基因）表达的蛋白质产物，主要产生于脂肪组织，向大脑反馈能量储存的信息并激活下丘脑中枢，调节进食和能量的消耗。此外，Leptin还可以通过直接或间接地影响下丘脑－垂体－性腺轴来调控动物的繁殖性能。笔者从Leptin的生物学基础、作用机理及繁殖调控等方面予以综述，并指出了其在家畜繁殖上的应用前景。     

瘦素受体研究进展

瘦素（Leptin）是肥胖基因（obese gene,ob基因)的蛋白质表达产物,是一种主要由脂肪细胞分泌的蛋白质,其作用主要是调节动物的能量代谢和生殖活动。与其它激素一样,Leptin必须与其受体特异性结合后才能发挥其生理功能。作者从瘦素受体（Leptin receptor或OB-R）角度出发,探讨了OB-R的结构、组织分布、生物学功能及Leptin与OB-R间的信号传导,为进一步研究Leptin的作用提供参考。     

营养等不同因素对奶牛血浆Leptin的调节

1 前言 Leptin是肥胖基因(ob基因)分泌的一种蛋白质,具有广泛的生物学效应.它参与调节食欲、能量平衡、繁殖、造血功能和免疫功能等.Leptin主要在是脂肪组织和含有脂肪细胞的组织表达,它也在乳腺、子宫、肝脏、心包、胎盘和肾脏表达.     

动物肥胖基因（ob）的研究进展

肥胖基因（ob）调节动物生长和维持能量平衡的生物学功能都是通过其产物——瘦素蛋白（Leptin）来实现的.因此,控制Leptin在动物体内的表达水平可有效降低脂肪含量,提高瘦肉率,从而为畜牧产业带来可观的经济效益.就ob基因的研究进展进行了系统性的综述.     

Leptin及其在动物繁殖方面的研究进展

Leptin（瘦蛋白）是肥胖基因（ob基因）表达的蛋白质产物，主要产生于脂肪组织，向大脑反馈能量储存的信息并激活下丘脑中枢，调节进食和能量的消耗，Leptin还可以通过直接或间接地影响了丘脑-垂体-性腺轴来调控动物的繁殖性能。本文从Leptin的生物学基础，作用机制及繁殖调控等方面予以综述。并指出了其在动物繁殖上的应用前景。     

肥胖基因ob研究进展

为了提高动物生产性能和改善产品品质,了解家畜控制肥胖、摄食与能量代谢的机制非常必要。长期以来,科学家从分子生物水平研究肥胖表型。目前与肥胖有关的基因已发现很多,其中obese(ob)基因是研究的重点,对其表达产物Leptin的作用机制已有较深入的了解。本文主要介绍了ob基因及     

Leptin的生物学功能及其对脂肪沉积的调控作用

Leptin（瘦素）是肥胖基因ob基因的表达产物,由脂肪细胞分泌,与下丘脑Leptin受体结合,可抑制食欲中枢,减少进食量,并通过兴奋交感神经系统,促进脂肪分解,增加产热,从而发挥降低体重,提高瘦肉率的功能。对Leptin的生物学功能及其对脂肪沉积的调控作用进行综述,以期为营养上调控畜禽肉品质,以及生产优质畜禽产品提供理论依据和科研基础。     

动物肥胖基因的研究进展

肥胖基因（obese gene,ob）是近年来克隆的一种基因.畜禽ob基因研究工作目前主要集中在基因克隆与定位、生理机能、多态性分析以及与生产性状之间的关系等方面.ob基因编码的瘦蛋白（Leptin）是由白色脂肪细胞分泌的一种蛋白质,具有降低动物采食量、维持动物能量平衡、调节动物的繁殖机能和提高动物的免疫功能等作用.近些年来,国内外很多科研单位对ob基因的研究投入了大量的工作,进行了较深入的研究.现就ob基因研究进展及其应用前景作一综述.     

肥胖基因及其产物的研究进展

Ob基因编码的Leptin具有降低脂肪，维持能量平衡，调节代谢、生殖、激素分泌，提高免疫机能等多方面的功能。本文在介绍Leptin、Leptin受体的基础上进一步对Leptin的生物学功能及其作用机制、Leptin的抗性做一简要论述，并提出了Leptin今后的研究方向及其在畜牧业上的应用前景。     

The brain-pituitary-adipocyte axis: role of leptin in modulating neuroendocrine function.

The recently discovered protein leptin has a molecular mass of 16 kDa, consists of 146 amino acids, and is synthesized and secreted by adipose tissue. Leptin affects feed intake, the neuroendocrine-axis, and immunological processes. The protein was first identified as the gene product that is deficient in the obese ob/ob mouse. Leptin serves as a circulating signal of nutritional status and plays a pivotal role in regulation of body weight, energy expenditure, growth, and reproduction.     

Leptin的生物学功能研究进展

瘦蛋白（L-eptin)是由肥胖基因（obese gene)编码，脂肪细胞分泌的一种激素，具有调节摄食行为，减少能量消耗和降低动物采食量的作用，从而提高动物的生产性能和经济效益。作者综述了Leptin的生物学功能，作用机理，表达调控并展望了Leptin在畜牧业中的应用前景。     

Biology of leptin in the pig

The recently discovered protein, leptin, which is secreted by fat cells in response to changes in body weight or energy, has been implicated in regulation of feed intake, energy expenditure and the neuroendocrine axis in rodents and humans. Leptin was first identified as the gene product found deficient in the obese ob/ob mouse. Administration of leptin to ob/ob mice led to improved reproduction as well as reduced feed intake and weight loss. The porcine leptin receptor has been cloned and is a member of the class 1 cytokine family of receptors. Leptin has been implicated in the regulation of immune function and the anorexia associated with disease. The leptin receptor is localized in the brain and pituitary of the pig. The leptin response to acute inflammation is uncoupled from anorexia and is differentially regulated among swine genotypes. In vitro studies demonstrated that the leptin gene is expressed by porcine preadipocytes and leptin gene expression is highly dependent on dexamethasone induced preadipocyte differentiation. Hormonally driven preadipocyte recruitment and subsequent fat cell size may regulate leptin gene expression in the pig. Expression of CCAAT-enhancer binding protein (C/EBP) mediates insulin dependent preadipocyte leptin gene expression during lipid accretion. In contrast, insulin independent leptin gene expression may be maintained by C/EBP auto-activation and phosphorylation/dephosphorylation. Adipogenic hormones may increase adipose tissue leptin gene expression in the fetus indirectly by inducing preadipocyte recruitment and subsequent differentiation. Central administration of leptin to pigs suppressed feed intake and stimulated growth hormone (GH) secretion. Serum leptin concentrations increased with age and estradiol-induced leptin mRNA expression in fat was age and weight dependent in prepuberal gilts. This occurred at the time of expected puberty in intact contemporaries and was associated with greater LH secretion. Further work demonstrated that leptin acts directly on pituitary cells to enhance LH and GH secretion, and brain tissue to stimulate gonadotropin releasing hormone secretion. Thus, development of nutritional schemes and (or) gene therapy to manipulate leptin secretion will lead to practical methods of controlling appetite, growth and reproduction in farm animals, thereby increasing efficiency of lean meat production.     

瘦素在生殖调节方面的研究进展

瘦素是一种由Leptin(ob)基因编码并主要由脂肪组织合成分泌的蛋白质类激素，广泛存在于各组织、器官中。其在调节机体脂肪和保持体重方面具有重要作用。对它的最初的研究主要集中在肥胖的作用，但以后的研究结果发现其缺乏不是造成单纯肥胖的原因。有研究表明，瘦素亦可作为一种代谢信号对下丘脑－垂体－性腺轴发挥功能。     

染色质开放性与动物胚胎发育关系的研究进展

染色质开放性是指核小体或转录因子等蛋白与真核生物染色质DNA结合后,对其他蛋白能否再结合的开放程度,这一特性能够反映转录活性.染色质结构是动态变化的,染色质开放性与动物生长发育、细胞分化等过程密切相关,基因组开放染色质高效精准定位可为解析基因表达调控机制提供重要线索.本文介绍染色质开放性检测方法、染色质开放性的影响因素...     

瘦素的生物学功能及其应用前景

瘦素可以降低脂肪含量、改变体组成、维持能量平衡，提高机体抗应激能力和免疫机能，促进动物新陈代谢。从而提高畜禽生产性能和经济效益。本文从调控机制、抗性、能量平衡及其在动物体内的作用等方面综述了瘦素生物学功能的研究进展，并从神经内分泌和分子生物学水平探讨瘦素的作用机理，指出其在畜牧业上的应用前景；     

Research Advance on the Relationship between Leptin and Reproduction Activities of Mammal

Studies in the last two decades found that Leptin not only involves in the regulation of mammalian ingestion and energy homeostasis,but also serves as a metabolic signal regulating the mammalian reproduction by acting on the hypothalamic-pituitary-gonadal (HPG) axis,the placenta and the uterus.Leptin gene is one of the most important candidate genes for research on livestock's growth,development and meat quality,and also for research on prolificacy of livestock due to its key role in regulating the mammalian embryo implantation.Therefore,it is of important scientific significance and potential application value in studying functions and mechanisms of Leptin and its receptor gene.This paper is to dwell on how Leptin regulates mammalian breeding activities including the onset of puberty,development of reproductive organs and gonads,secretion of reproductive hormones,and embryo implantation,and also on how some reproduction activities influence the Leptin secretion in the body.