共查询到19条相似文献,搜索用时 500 毫秒
1.
猪繁殖与呼吸综合征(PRRS)是由猪繁殖与呼吸综合征病毒(PRRSV)引起的一种主要表现为母猪繁殖障碍和新生仔猪呼吸道疾病的致死性传染疾病,是严重影响世界养猪业的经济性疾病之一,对该病的预防、发病后的诊断及时处理控制是猪场面临的主要问题之一。本文综述PRRSV生物学及分子免疫学特征、PRRS的诊断、免疫防控等方面的研究进展,为PRRS的深入研究及猪场对该病的控制提供参考。 相似文献
2.
猪繁殖与呼吸综合征(PRRS)是由PRRSV病毒引起和一种高度传染,广泛流行的疾病,PRRSV极易变异,对现代养殖业危害巨大,是引起夏季高热病爆发的最主要的因素,作者就PRRS的病原特点,流行性,防控技术作一专题论述。 相似文献
3.
4.
[目的]为阐明哺乳动物雷帕霉素靶点(mammalian target of Rapamycin,mTOR)信号通路在调控猪繁殖与呼吸综合征病毒(porcine reproductive and respiratory syndrome virus,PRRSV)复制过程中的作用,探索防控该病传染的新途径.[方法]PRRS... 相似文献
5.
6.
7.
[目的]分析猪细环病毒1型(TTSuVl)感染与猪繁殖与呼吸综合征(PPRS)的发生是否存在相关性.[方法]采集40头临床疑似PRRS病猪血清和40头同群健康猪血清,确认PRRS病猪与猪繁殖与呼吸综合征病毒(PPRSV)亚临床感染猪,用荧光定量PCR方法检测TTSuV1和PRRSV载量,进行差异比较和相关性分析.[结果]常规PCR结合荧光定量PCR检测确认有31头PRRS病猪和27头PPRSV亚临床感染猪,前者PRRSV载量极显著(P<0.01)高于后者;虽然PRRS病猪的TTSuV1载量高于PRRSV亚临床感染猪,但其差异不显著.PRRSV感染猪的血清中的TTSuV1载量与PRRSV载量之间无显著(P>0.05)相关性.[结论]TTSuV1感染与PRRS发生之间可能没有相关性. 相似文献
8.
9.
10.
猪蓝耳病是由猪繁殖与呼吸综合症病毒(PRRSV)引起的一种严重危害养猪业的病毒性传染病猪,又称猪繁殖与呼吸综合症(PRRS)。介绍了猪蓝耳病的病原、传播方式、临床症状、病理变化、诊断和防治措施。 相似文献
11.
高致病性猪繁殖与呼吸综合征(PRRS)俗称蓝耳病,是由猪繁殖和呼吸综合征病毒变异株引起的一种急性高致死性疫病,该病是一种免疫抑制病,其感染宿主唯一,且常常继发其他病原感染。PRRS发病时间间隔为2~37d,一般为5d左右,任何年龄、品种猪只均可发病。猪对很多PRRSV的感染途径敏感,包括口腔、鼻腔、肌肉、腹腔和生殖道。该病传染性高,并且只要有10个或者更少的病毒粒子,就可发生PRRS。疫苗免疫是预防PRRS的重要手段之一,目前有灭活疫苗和弱毒疫苗可供使用。针对高致病性猪蓝耳病的有效防控研究正在许多科研机构深入开展,能引起猪体对PRRSV产生保护性抗体的免疫原性基因的筛选、改造和利用等相关研究正加紧进行,以期研制一种安全高效的PRRS疫苗。 相似文献
12.
河南濮阳某养猪场怀孕母猪出现流产,产死胎、木乃伊胎,仔猪发生呼吸性疾病等症状,发病率达60%,日死亡1~2头。结合临床症状、病理变化和实验室诊断,确诊为猪繁殖与呼吸综合症。随后采用综合防治措施对疫病进行控制,综合治疗后7d,全群情况好转,采食量恢复正常,死亡停止且无新增病例。最后对繁殖与呼吸综合症的发病原因、防制措施进行了讨论。 相似文献
13.
猪繁殖与呼吸综合征(porcine reproductive and respiratory syndrome,PRRS)是由PRRS病毒(PRRSV)引起的以母猪繁殖障碍和仔猪呼吸困难、病毒血症为典型症状的一种传染性疾病,给世界养猪业带来巨大的经济损失。深入研究PRRSV的相关致病机制可为该病防控奠定理论依据。在对PRRSV的研究中,非结构蛋白2(non-structural protein 2, Nsp2)一直是研究的热点,文章综述了Nsp2与遗传变异、病毒致病性、病毒复制、免疫调控和重组疫苗与分子标签等相关的研究进展。Nsp2基因序列在对疫苗毒株的鉴别诊断中发挥重要作用。 相似文献
14.
TaoXING XingxingYU JunZHANG HongfeiZHANG HaigenWANG GuangshengZHOU MinZHANG ChuanminLIU JinguiLI 《农业科学与技术》2017,18(1)
Abstract Porcine reproductive and respiratory syndrome(PRRS)is the severest disease of pigs worldwide,caused by a highly genetically diverse RNA virus,called Porcine reproductive and respiratory syndrome virus(PRRSV).The research summarized the genome characteristics of PRRSV particles and the most updated knowledge of structure protein function,and introduced the intellectual of PRRSV transmission and host immune response,which is very important for prevention and control for PRRS.A report showed that mass vaccination can stabilize the immunity of the entire herd,and this is the first required step for a PRRS eradication plan.However,the attenuated live vaccines may not achieve a valid prevention.The final goal of the EU project is to develop new generation,efficacious and safe maker vaccines that can be adapted to temporary changes and geographical differences.Robinson reported that broadly antibodies could neutralize all rapidly evolving typeⅠand typeⅡviruses,while further studies are expected to elucidate mechanisms of neutralizing antibody production and maturation and to investigate conserved epitope targets of cross-neutralization in this rapidly evolving virus. 相似文献
15.
Porcine reproductive and respiratory syndrome (PRRS) is characterized by reproductive failures in sows and respiratory diseases in pigs of all ages. PRRS virus (PRRSV) is its causative agent and has caused huge economic losses in the swine industry. Porcine sialoadhesin (pSn) is a putative receptor of PRRSV. Previous studies have shown that a pSn V-set Ig-like domain is significant in PRRSV infection. However, its structural details are not fully known, hindering our deep understanding of PRRSV infection. In this study, we successfully cloned, expressed and purified the pSn V-set Ig-like domain in Drosophila S2 cells. Then we tried to crystallize the target protein and predicted its structure. This will establish the foundation for the further structural study of pSn, deepen our understanding of the invasion mechanism of PRRSV, and support the structural information for the development of clinical drugs and vaccines against PRRSV. 相似文献
16.
猪病毒病抗体及病原的检测及分析 总被引:2,自引:1,他引:1
[目的]研究猪场猪病毒病的抗体水平及感染情况,为猪病的防制提供理论依据。[方法]抽样采集各类猪只血液和组织样品,分别应用酶联免疫吸附试验(ELISA)、聚合酶链式反应(PCR)及反转录聚合酶链式反应(RT-PCR)方法对猪瘟(CSF)、猪伪狂犬病(PR)、猪繁殖与呼吸综合征(PRRS)及猪圆环病毒病(PCV-2)的抗体、病原进行检测分析。[结果]结果表明,猪场存在CSF、PR野毒感染;PRRS免疫抗体水平不太理想,阳性感染率为3.3%~17.3%;PCV-2阳性感染率为0~9.6%。[结论]试验猪场病毒病,应采取完善的综合措施才能获得理想的效果。 相似文献
17.
猪繁殖与呼吸综合症免疫学研究 总被引:16,自引:1,他引:16
猪繁殖与呼吸综合症是由猪繁殖与呼吸综合症病毒引起的高度传染性病毒病。笔者就呼吸综合症病毒的理化特性、生物学特征、基因组构成、病毒复制、免疫学特征以及疫苗等作一简述 相似文献
18.
Mengmeng ZHAO Juanjuan QIAN Jiexiong XIE Tiantian CUI Songling FENG Guoqiang WANG Ruining WANG Guihong ZHANG 《农业科学与工程前沿(英文版)》2016,3(2):153
Porcine reproductive and respiratory syndrome (PRRS) is considered to be one of the most important infectious diseases impacting the swine industry and is characterized by reproductive failure in late term gestation in sows and respiratory disease in pigs of all ages. The nonstructural protein 9 gene, Nsp9, encoding the RNA-dependent RNA polymerase, is generally regarded as fairly conserved when compared to other viral proteins. Antibodies against Nsp9 will be of great importance for the diagnosis and treatment of the causal agent, PRRS virus. A study was undertaken to generate polyclonal antibodies against the immunodominant Nsp9. For this purpose, the Nsp9 was expressed in Escherichia coli and subsequently used as an antigen to immunize New Zealand rabbits. Antiserum was identified via an indirect ELISA, and then verified based on the ability to react with both naturally and artificially expressed Nsp9. Results of virus neutralization test showed that this antiserum could not neutralize the PRRSV. Nevertheless, this antiserum as a diagnostic core reagent should prove invaluable for further investigations into the mechanism of PRRS pathogenesis. 相似文献