犬子宫蓄脓症

犬子宫蓄脓是临床上常见的产科疾病,主要发生在犬发情后期,根据临床症状可将其分为开放型子宫蓄脓和闭锁型子宫蓄脓。犬子宫蓄脓是在子宫内膜囊性增生、孕酮浓度增加、雌激素浓度降低和细菌感染等因素作用下子宫发生的炎性病变,该病无特殊疗法,彻底根治必须进行手术治疗。在此对犬子宫蓄脓的病因、诊断及治疗进行综述。     

犬子宫蓄脓症

犬子宫蓄脓是临床上常见的产科疾病,主要发生在犬发情后期,根据临床症状可将其分为开放型子宫蓄脓和闭锁型子宫蓄脓。犬子宫蓄脓是在子宫内膜囊性增生、孕酮浓度增加、雌激素浓度降低和细菌感染等因素作用下子宫发生的炎性病变,该病无特殊疗法,彻底根治必须进行手术治疗。在此对犬子宫蓄脓的病因、诊断及治疗进行综述。     

犬子宫蓄脓病因学研究进展

犬子宫蓄脓是临床上常见的产科疾病,据临床症状可将其分为闭锁型子宫蓄脓和开放型子宫蓄脓。犬子宫蓄脓主要发生在犬发情后期,此期受孕酮浓度增加和雌激素浓度降低的影响,使子宫细胞的免疫水平降低。孕酮浓度增加使子宫内膜增生和腺体分泌增加,同样有利于外来细菌的生长、繁殖。子宫黏膜受到外来细菌的入侵发生病变,子宫分泌物增多。若在子宫颈关闭的情况下,不会有分泌物排出;但若子宫颈处于开放状态,则主要排出恶臭、多血的黏液脓性分泌物。另外,犬子宫蓄脓的发生与犬的年龄、品种可能也有一定的相关性。总之,犬子宫蓄脓是在子宫内膜囊性增生、孕酮对子宫内膜连续刺激和细菌感染等因素作用下的子宫炎性病变表现。     

一例肥胖犬开放型子宫蓄脓的诊疗体会

犬肥胖症是一种主要因营养过剩或缺乏运动而导致脂肪组织过度蓄积的综合症(何英等,2009).当犬体重超过正常体重20％时,犬的健康就将受到严重威胁,甚至引起心脏病、关节炎、皮肤病等(马宗毅等,2008).犬子宫蓄脓主要发生于发情后期,根据临床症状分为开放型和闭锁型子宫蓄脓.子宫蓄脓是子宫内膜囊性增生、孕酮浓度增加、雌激素浓度降低和细菌感染等因素造成子宫发生的炎性病变(张志宏等,2010).笔者2010年12月在门诊收治一例临床中较少见的犬肥胖症并发开放型子宫蓄脓,现将诊疗过程报告如下.     

犬子宫蓄脓症的形成原因及诊治

犬子宫蓄脓是母犬产科常见的一种急性或慢性疾病，临床上多发生于犬发情后期，发病率高。临床症状包括开放型和闭锁型子宫蓄脓。犬子宫蓄脓是在子宫内膜增生、孕酮浓度增加、雌激素数量减少和接触到感染细菌等因素所引起的子宫炎性病变，该病无特殊治疗方法，要想彻底根治，必须采取卵巢和子宫切除手术治疗。     

诊治犬子宫蓄脓合并子宫角扭转病例

<正>子宫蓄脓也称子宫积脓,是未绝育中老年母犬常见的疾病,患犬子宫壁增厚,子宫腔增大,子宫内充满脓性分泌物。犬子宫角扭转在临床较少见,以单侧扭转为主,一般怀孕母犬妊娠末期、分娩期和使用催产剂,以及子宫积液和子宫息肉等时可发生~([1])。犬子宫蓄脓合并子宫角扭转的情况在临床并不多见,报道的也并不多~([2])。笔者现将临床所见一例犬子宫蓄脓合并子宫角扭转病例的诊治介绍如下。     

一例犬子宫蓄脓的诊治

犬子宫蓄脓是指犬子宫腔内积聚大量脓液,并伴有子宫内膜异常增生和细菌感染的一种母犬常见的产科疾病.犬子宫蓄脓一般以双角子宫同时蓄脓居多,很少出现单侧子宫角蓄脓.笔者选取在动物医院临床接诊的疑似单侧子宫蓄脓病例,通过临床症状做出初步诊断,并结合患犬病史、血液检查、生化指标、X射线检查以及B超检查等实验室检查进行综合分析,作出确诊.本文对诊断和治疗过程进行分析,以期为临床治疗犬单侧子宫蓄脓病例提供参考.     

袁标1,张海2,邓珊珊3,蔺俐仲4,徐春志2*,袁林1,景书灏2,杨源2,刘艳2,袁翠霞2,杨峰2(1.贵阳市息烽县农业农村局,贵州贵阳551100;2.贵阳市动物疫病预防控制中心,贵州贵阳

犬子宫蓄脓是指犬子宫腔内积聚大量脓液,并伴有子宫内膜异常增生和细菌感染的一种母犬常见的产科疾病。犬子宫蓄脓一般以双角子宫同时蓄脓居多,很少出现单侧子宫角蓄脓。笔者选取在动物医院临床接诊的疑似单侧子宫蓄脓病例,通过临床症状做出初步诊断,并结合患犬病史、血液检查、生化指标、X射线检查以及B超检查等实验室检查进行综合分析,作出确诊。本文对诊断和治疗过程进行分析,以期为临床治疗犬单侧子宫蓄脓病例提供参考。     

20例老龄犬子宫蓄脓的诊治

犬子宫蓄脓,是指犬子宫内积有脓液,是兽医临床上中老年母犬较常见的生殖系统疾病,临床上可严重损害犬的健康和繁殖能力。近年来随着老龄犬数量的大幅度增加,老龄犬的健康问题特别是老龄犬子宫蓄脓的诊治,也越来越引起兽医和畜主的重视。为进一步探讨老龄犬子宫蓄脓的发病规律,本文通过回顾分析2014年10月至2015年9月于云南农业大学动物医院收集的20例老龄犬子宫蓄脓的病例资料,来分析老龄犬子宫蓄脓的病因、症状、诊断、治疗,为临床上老龄犬子宫蓄脓的诊断与治疗提供更确切的指导。     

一例犬子宫蓄脓的诊治

犬子宫蓄脓是临床上发病率较高的一种犬产科疾病,常在母犬发生子宫内膜炎和子宫内膜囊性增生后继发细菌感染,导致子宫内蓄积大量脓性渗出物不能排出,最后发展为子宫蓄脓。本病多见于发情后2～3个月的未经产或经产而屡配不孕的中高龄犬。笔者采用临床检查、病原分离等方法。对1例疑似子宫蓄脓病犬进行确诊,采取手术切除并配合抗生素治疗取得成功,现报告如下。     

一例犬子宫蓄脓的诊断及手术治疗

本试验对一例患有子宫蓄脓的西施犬通过询问病史、临床检查、血常规检测、X光及B超检查进行确诊,采用手术法治疗。结果显示,血常规检查发现白细胞、中性粒细胞均增多,X光检测到明显膨大的子宫,B超影像可观察到子宫角为圆腔状的黑色暗区,子宫壁增生变厚产生无回声液性暗区。对于子宫蓄脓的诊断,血常规检查显示体内有炎症变化,X光和B超确诊病犬为开放性子宫蓄脓,对病犬采取手术疗法,彻底切除卵巢和子宫。病犬术后恢复良好。     

Surgical uterine drainage and lavage as treatment for canine pyometra

Pyometra is a common post-oestral syndrome in bitches. Classical treatment consists of either ovariohystorectomy or medical intervention. Surgical uterine drainage and lavage via direct trans-cervical catheterisation using a 5% povidone-iodine in saline solution was performed successfully in 8 bitches with pyometra. All bitches conceived and whelped without complications subsequent to this treatment. It is concluded that this method offers an effective alternative treatment for canine pyometra with shorter recovery times as well as good clinical recovery and pregnancy rates in bitches destined for further breeding.     

Uropathogenic virulence factors in isolates of Escherichia coli from clinical cases of canine pyometra and feces of healthy bitches

Escherichia coli is commonly isolated in canine pyometra, but little is known of the virulence factors that may be involved in the precipitation of this disease. The aim of this study was to compare the prevalence of uropathogenic virulence factor (UVF) genes in E. coli isolates from canine pyometra and from feces of healthy bitches to evaluate their role in the pathogenesis of pyometra. E. coli from 23 cases of canine pyometra and from the feces of 24 healthy bitches were analyzed, by polymerase chain reaction, for UVF genes associated with canine and human urinary tract infections (UTIs). The prevalences of UVFs in E. coli from canine pyometra were similar to that in canine and human uropathogenic E. coli. The prevalence of pap was greater (P=0.036) for E. coli from pyometra (52%) than for fecal isolates (21%), and the papGIII allele was present in all pap-containing isolates. The prevalences of genes for alpha-haemolysin and cytotoxic necrotising factor 1 were not significantly higher (P=0.075) in E. coli from pyometra than from feces. The proportion of pyometra strains with >or=3 UVFs was higher (P=0.039) than that of fecal strains, suggesting that possession of >or=3 UVF genes enhances the pathogenicity of the strain. Our findings demonstrate that E. coli associated with canine pyometra are similar to uropathogenic strains, and that operons that encode P fimbriae, alpha-haemolysin and cytotoxic necrotising factor 1 probably enhance the virulence and pathogenicity of the strain in the canine genital tract.     

子宫蓄脓对犬子宫内膜组织中IGF-2及IGF-1R蛋白表达的影响

探讨IGF-2及IGF-1R蛋白质在子宫蓄脓的表达及与子宫蓄脓发病的相关性。采用免疫组织化学PV法与Western blotting检测5例正常子宫内膜(对照组)、19例子宫蓄脓(试验组)子宫内膜组织中IGF-2及IGF-1R的表达情况。结果表明,免疫组化与Western blotting检测结果一致,IGF-2和IGF-1R在蓄脓子宫组中的表达量极显著高于正常子宫(P<0.01)。对子宫蓄脓组中IGF-1R与IGF-2进行相关性分析,免疫组化结果表明IGF-1R与IGF-2之间低度相关(ｒ=0.423),Western blotting结果显示IGF-1R与IGF-2之间高度相关(ｒ=0.927)。结果提示,IGF-2阳性表达上调及IGF-1R的异常高表达,在子宫蓄脓的发生和发展过程中可能具有重要作用。     

Effect of Canine Pyometra on IGF-2, IGF-1R Proteins Expressions of Endometria

To investigate the expression of IGF-2 and IGF-1R protein in endometria of canine pyometra and analyze the possible correlation with the incidence of canine pyometra.Immunohistochemistry PV method and Western blotting were used to measure the IGF-2 and IGF-1R expression characteristic of 5 normal endometria and 19 endometria of canine pyometra.The results showed that the IGF-2 level of endometria from pyometra group was extremely significant higher than that of control group by immunohistochemistry and Western blotting (P<0.01).The positive expression rate of IGF-1R in endometria of canine pyometra compared with that in the normal endometria was extremely significant higher by immunohistochemistry and Western blotting (P<0.01).The correlation analysis of IGF-2 and IGF-1R in canine pyometra showed that the result of immunohistochemistry was low correlation (ｒ=0.423), the result of Western blotting was high correlation (ｒ=0.927).The data suggested that increased expression of IGF-2 and IGF-1R played an important role in occurrence of canine pyometra.     

Histological characteristics of canine deciduoma induced by intrauterine inoculation of E. coli suspension.

Canine deciduoma could be induced in the diestrous uterus by an intrauterine inoculation of a culture suspension of E. coli originally isolated from naturally occurring canine pyometra. These deciduomas had the same histological findings as those of naturally occurring canine pyometra with so called "Swiss cheese endometrium". This suggests a possibility that the canine pyometra is a kind of naturally occurring decidual reaction (deciduoma) induced by one of several triggers such as bacterial infection.     

Prostaglandin F2 alpha treatment of canine pyometra

Immediate and long-term outcomes of prostaglandin F2 alpha treatment for canine pyometra were studied in 10 bitches. Examination of pretreatment uterine biopsy specimens, taken for histopathologic diagnosis and classification of disease severity, revealed either type III or IV pyometra. Dinoprost tromethamine (0.25 or 0.5 mg/kg of body weight, SC) was given once daily for 3 days. Bitches were bred at the first posttreatment estrus and monitored for a minimum of one year. When pure cultures of Escherichia coli (n = 3) or Staphylococcus aureus (n = 1) were obtained from the vagina, these bacteria also were found in the uterus. Pretreatment WBC counts often did not reflect the severity of histopathologic findings in the uterus, but posttreatment WBC counts were useful in monitoring response to treatment. Four bitches produced a litter within one year of treatment. Four bitches (40%) had recurrence of pyometra within one year of treatment, and these same bitches had another recurrence after an additional prostaglandin treatment. Three additional bitches had a recurrence by 27 months after therapy, establishing a total recurrence rate of 77% (7/9). Results suggested that subclinical disease may persist after treatment, with clinical recurrence during diestrus. Despite the high recurrence rate, it was concluded that this treatment is a practical treatment for canine pyometra when reproduction is desired.     

犬子宫蓄脓症诊断与治疗方法的研究

为了研究犬子宫蓄脓症的诊断与治疗方法。收集来自合肥动物保健中心、池州贝乐康宠物医院的20例子宫蓄脓症患犬病例,并通过分析上述病例的临床症状、实验室检查、仪器检查探究了子宫蓄脓症最为有效、最合理的诊断与治疗方法。研究结果表明,血常规、血液生化、B超、X线对于子宫蓄脓的诊断有着重要的应用价值,在针对该病的预防与治疗上应尽早实施卵巢子宫摘除术。     

Primary lymphoma of the uterine horn in a Lhasa Apso dog

Primary lymphomas of the canine female genital tract are uncommon tumours. A 9-year-old intact female Lhasa Apso dog presenting with a closed pyometra underwent an ovariohysterectomy (OHE), and the hyperplastic uterine horn along with multiple follicular cysts on the right ovary was examined by histological analysis. Severe infiltration of medium-sized lymphocytes with strong positive immunoreactivity for CD79a and numerous anaplastic features was detected in the unilateral uterine horn, and the dog was diagnosed as having extranodal marginal zone B-cell lymphoma (MZBCL). The present case reports an extremely rare occurrence of primary lymphoma involving the uterine horn in a dog and describes histological characteristics of the tumour for definite diagnosis.     

Pyometra with inguinal herniation of the left uterine horn and omentum in a Beagle dog

Objective: To describe a unique case of pyometra with inguinal herniation of the left uterine horn and omentum. Case summary: A 7‐year‐old, 19 kg, intact female Beagle dog presented for surgical treatment of presumptive pyometra and biopsy of a caudal abdominal mass in the left inguinal mammary gland region. Ventral midline celiotomy was performed, and a distended, fluid‐filled uterus with passage of the distal aspect of the left uterine horn through the left vaginal process into the inguinal canal was identified. The patient recovered uneventfully following ovariohysterectomy and left inguinal herniorrhaphy. New or unique information provided: This is the first documented report of inguinal herniation of a uterine horn associated with a pyometra.