Expression of Chicken Toll-Like Receptors and Signal Adaptors in Spleen and Cecum of Young Chickens Infected with Eimeria tenella |
| |
| Authors: | ZHOU Zuo-yong HU Shi-jun WANG Zhi-ying GUO Zhi-li QIN Bo NIE Kui |
| |
| Affiliation: | 1、Department of Veterinary Medicine, Rongchang Campus of Southwest University, Chongqing 402460, P.R.China
2、College of Animal Science and Technology, Southwest University, Chongqing 400715, P.R.China |
| |
| Abstract: | Toll-like receptors (TLRs) are a group of highly conserved molecules which initiate the innate immune response to pathogens by recognizing structural motifs of microbes. Understanding the changes in chicken Toll-like receptors (ChTLRs) and signal adaptors expression that occur with Eimeria tenella infection will help to elucidate the molecular basis of immune control of coccidiosis caused by Eimeria. The present study detected the dynamic changes in the expression of ChTLRs and associated signal adaptors in the spleen and cecum of E. tenella-infected chickens during the early stage of infection. The results showed that the expression peak for ChTLRs, MyD88 and TRIF occurred at 12 h post-infection (hpi), ChTLR3, ChTLR15 and MyD88 mRNA expression in the spleen of E. tenella infected chickens were significantly higher (P<0.05) than that of negative control chickens, and there were similar tendencies of these molecules expression in the cecum and spleen of E. tenella-infected chickens. The expression of MyD88 was upregulated at four time points in the cecum of E. tenella-infected chickens. The results of this study indicate that ChTLR3, ChTLR15 and MyD88 play a role in young chickens infected with E. tenella. |
| |
| Keywords: | Eimeria tenella signal adaptors Toll-like receptors spleen and cecum chicken |
| 本文献已被 维普 ScienceDirect 等数据库收录！ |
| 点击此处可从《农业科学学报(英文版)》浏览原始摘要信息 |
|
点击此处可从《农业科学学报(英文版)》下载全文 |
