| 钙磷胶体复合剂的安全性及药效检测 |
| 投稿时间：2007-09-17 修订日期：2007-12-18 点此下载全文 |
| 引用本文：郭玺,马永华,赵宝玉,霍星华,万学攀.钙磷胶体复合剂的安全性及药效检测[J].西北农业学报,2008,17(3):54~57 |
| DOI:10.7606/j.issn.1004-1389.2008.03.013 |
| 摘要点击次数: 38 |
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| 作者 | 单位 | E-mail | | 郭玺 | 西北农林科技大学动物医学院, 陕西杨凌, 712100 | | | 马永华 | 汉中职业技术学院, 陕西汉中, 723001 | | | 赵宝玉 | 西北农林科技大学动物医学院, 陕西杨凌, 712100 | zhaobaoyu12005@163.com | | 霍星华 | 西北农林科技大学动物医学院, 陕西杨凌, 712100 | | | 万学攀 | 西北农林科技大学动物医学院, 陕西杨凌, 712100 | |
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| 中文摘要:以氯化钙为主要原料,添加磷酸钙和羟乙基纤维素,制备了钙磷胶体复合剂,经检测含钙量为115±5mg/mL、含磷量为16.4±2mg/mL。试验小鼠n=20以0.8mL/20g(体重)的最大剂量一日灌服2次,7d后观察无中毒表现,剖检后组织器管无肉眼可见异常。试验组小鼠n=20以0.4mL/20g(体重)的剂量一日2次连续灌服7d后,无中毒及死亡现象,小鼠平均体重由20.24±1.211g增加到23.35±1.130g,体重增加情况与对照组小鼠无差异。以100mL/只灌服奶山羊(n=5)后,血钙、血磷浓度在2~3h达到峰值(P<0.05),而且可维持6h左右。 |
| 中文关键词:胶体 氯化钙 磷酸钙 小鼠 奶山羊 |
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| Investigation of the Safety and Efficiency of the Calcium and Phosphorus Gel |
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| Abstract:Calcium chloride with calcium phosphate and hydroxyethyl cellulose was compounded to form calcium and phosphorus gel.The Ca and P contents were 115±5 mg/mL and 16.4±2 mg/mL respectively.Mice(n=20) were administered with calcium and phosphorus gel with 0.8 mL/20 g body weight twice on the first day.After 7 days, it didn't induce toxicosis and there were no obviously pathological changes in the important tissue and organ.When the mice in the experimental group(n=20) were administered with calcium and phosphorus gel for 7 days with the dose of 0.4 mL/20 g body weight twice daily, it did not induce toxicosis or death.The averageweight of the mice increased from 20.24±1.211 g to 23.35±1.130 g.The increased trend was as the same as the control group.The milk goats(n=5) were administered with calcium and phosphorus gel with 100 mL each.The serum Ca and P concentrations were increased and reached the peak concentration after 2~3h(P<0.05).And the high serum Ca and P concentrations were maintained about 6h. |
| keywords:Gel Calcium chloride Calcium phosphate Mice Milk goat |
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