Structural remodelling of the heart valves extracellular matrix during embryo development |
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Authors: | Luis Felipe Falla Zuñiga Yhoiss Smiht Muñoz Cerón Liliana Salazar |
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Institution: | 1. Medical intern, Universidad del Valle, Cali, Colombia;2. Universidad del Valle, Cali, Colombia;3. Department of Morphology, Universidad del Valle, Cali, Colombia |
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Abstract: | Alterations in heart valve development represent more than 20% of congenital cardiovascular malformations. Most of the functional properties of heart valves depend on extracellular matrix. Despite its relevance, little is known about fibrillar components on developing stages. Our objective is to define histological changes on valves fibrillar components in late embryonic development of Mus musculus. We found type III collagen as the predominant fibre type in the ECM in prenatal stages followed by a switch to a type I predominance for postnatal ages. The change in fibrillar components is necessary to support the normal mechanical function of adult heart valves. |
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Keywords: | collagen type I collagen type III extracellular matrix heart valves mice |
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