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Cellular transformation by human papillomavirus DNA in vitro |
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| Authors: | S L Watts W C Phelps R S Ostrow K R Zachow A J Faras |
| Abstract: | Molecularly cloned DNA's of human papillomaviruses HPV-5 and HPV-l induced morphological transformation of mouse C127 cells in culture. Single-cell clones of cells transformed by papillomavirus contained multiple persistent episomal copies of the transfected DNA species and were analyzed for growth characteristics indicating malignant potential. |
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