Two Cases of Metastatic Parathyroid Carcinoma in Male C3H Mice Following Irradiation |
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Authors: | Yasushi Ohmachi Midori Yoshida Toshiaki Ogiu |
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Institution: | 1.National Institute of Radiological Sciences, Anagawa 4-9-1, Inage-ku, Chiba 263-8555, Japan;2.National Institute of Health Sciences, Kamiyoga 1-18-1, Setagaya-ku, Tokyo 158-8501, Japan |
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Abstract: | White nodules were observed in the thyroid in two male C3H mice (at 99 and 122 weeks of
age) exposed to fast neutrons at the age of 8 weeks. Histopathologically, in both cases,
tumors were developed in the region corresponding to the parathyroid gland, and the tumor
cells were arranged in a solid sheet or nest-like structures. Necrosis, cell debris and/or
hemorrhage were sometimes seen in the center of the tumor structures. Tumor cells were
small and uniform with scanty cytoplasm, cell margins were indistinct, and basally located
tumor cells were aligned along the vascular stroma. Mitotic figures were frequently
observed. Metastasis to the renal cortex was observed in both cases. These cases were
diagnosed as parathyroid carcinoma. A parathyroid tumor is an extremely rare endocrine
tumor in mice, regardless of whether the tumor is spontaneous or experimentally induced.
These cases may have been induced by neutron-exposure; however, how radiation induces
parathyroid carcinoma in mice is not clear. |
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Keywords: | parathyroid carcinoma C3H mouse neutron metastasis |
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