氟尼辛葡甲铵解热镇痛作用药效学研究

通过小白鼠醋酸扭体法、家兔蛋白胨致热法对氟尼辛葡甲铵(FM)解热、镇痛作用进行了药效学研究.结果表明:氟尼辛葡甲铵具有明显的解热、镇痛作用.与对照组相比,氟尼辛葡甲铵4个剂量组(1.25、2.5、5、10 mg/kg)对醋酸所致的小鼠扭体反应均有极强的抑制作用,抑制率最高达100%.2.5 mg/kg的FM镇痛率即达82.7%,明显强于双氯芬酸钠(65.4%)和安乃近(58.7%).对蛋白胨引起的家兔发热的解热效果,氟尼辛葡甲铵高剂量组(4 mg/kg)优于安乃近组(0.2 g/kg)(P<0.05)和氨基比林组(0.2 g/kg)(P<0.01).中剂量氟尼辛葡甲铵组(2 mg/kg)解热作用稍逊于安乃近组,但差异不显著.低剂量氟尼辛葡甲铵组(1 mg/kg)解热作用与氨基比林组相当.

Pharmacodynamic studies on antipyretic and analgesic effects of flunixin meglumine

Flunixin meglumine(FM) is a kind of non-steroidal anti-inflammatory drug used special for animals.It has many advantages,such as high efficiency and little side effects,etc.To study its antipyretic and analgesic effects,experiments of twisty response induced by acetic acid in mice and fever induced by peptone in rabbits were performed.Results showed that FM had obviously antipyretic and analgesic effects.Compared with control group,the four dosage groups of FM(1.25,2.5,5,10 mg/kg) could significantly inhibit twisty response in mice induced by acetic acid(P<0.05),and the maximal inhibitory rate reached 100 %.The pain-inhibition rate of FM(2.5 mg/kg) reached 87.7 %,which was obviously higher than that of diclofenac sodium(65.4 %) and analgin(58.7 %).FM high dosage group(4 mg/kg) also displayed significantly stronger antipyretic effects on fever in rabbits induced by peptone than those of 0.2 g/kg analgin-treated group(P<0.05) and 0.2 g/kg aminopyrine-treated group(P<0.01),respectively.Although effects of moderate dosage FM(2 mg/kg) was a bitter lower than that of analgin-treated group,there were no statistically significant differences between them.Antipyretic effects of low dosage FM(1 mg/kg) was similar to that of aminopyrine-treated group.