Submucosal vestibulo-vaginal administration of cloprostenol (Oestrophan-Spofa) in cows in relation to estrus activity, conception, and the level of progesterone in milk

Trials were performed to examine the effectiveness of 250 micrograms (1 ml) of cloprostenol (Oestrophan Spofa) implantation under the mucous membrane of the vaginal vestibule of 128 cows with a clinically pronounced corpus luteum on ovaries. Within 72 hours from administration, oestrus was observed in 112 animals (85.5%). Out of the 97 cows inseminated, 63 cows (64.94%) got in calf. The effectiveness of the luteolytic action was examined on the basis of progesterone check in milk in 56 treated cows. The submucous implantation of cloprostenol rapidly degraded the function of the corpus luteum since from the original level of 14.78 ng/ml progesterone decreased to 0.87 ng/ml within 72 hours. However, luteolysis did not affect all the corpora lutea. Hence the submucous administration of cloprostenol was found to be effective, and at the same time, highly economical, owing to a substantial reduction in the costs of reproduction control as well as the costs of production.