O-乙基磷酰二氯气相色谱分析方法研究

目的]建立药物中间体O-乙基磷酰二氯的定量分析方法。方法]采用气相色谱法,以十一烷为内标物,用氢火焰离子化检测器对O-乙基磷酰二氯进行定量分析。结果]采用气相色谱法定量分析药物中间体O-乙基磷酰二氯,O-乙基磷酰二氯在一定浓度下的线性相关系数R2=0.999 3,标准偏差为0.173 3,变异系数为0.179 4%,平均回收率为99.74%。结论]气相色谱法定量分析药物中间体O-乙基磷酰二氯,方法简单、快速,结果准确,灵敏度、精密度和检测限均符合药物残留分析的要求。

Gas Chromatography Analysis Method of Ethyl Dichlorophosphate

Objective]The paper was to establish the quantitative analysis method of drug intermediate ethyl dichlorophosphate by gas chromatography(GC).Method]Using gas chromatography,with undecane as internal standard,ethyl dichlorophosphate was carried out quantitative analysis by hydrogen flame ionization detector(FID).Result]When intermediate ethyl dichlorophosphate was carried out quantitative analysis by gas chromatography,its linear correlation coefficient was 0.999 9 under certain concentration,the standard deviation was 0.173 3,the variation coefficient was 0.179 4%,and the average recovery was 99.74%.Conclusion]Gas chromatography method is simple,sensitive and accurate for quantitative analysis of ethyl dichlorophosphate,its sensitivity,precision and detection limit meet the requirements of drug residue analysis.