Cerebellum shapes hippocampal spatial code |
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Authors: | Rochefort Christelle Arabo Arnaud André Marion Poucet Bruno Save Etienne Rondi-Reig Laure |
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Affiliation: | Neurobiologie des Processus Adaptatifs (UMR 7102), Navigation, Memory, and Aging (ENMVI) Team, Université Pierre et Marie Curie-Centre National de la Recherche Scientifique (CNRS), F-75005 Paris, France. |
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Abstract: | Spatial representation is an active process that requires complex multimodal integration from a large interacting network of cortical and subcortical structures. We sought to determine the role of cerebellar protein kinase C (PKC)-dependent plasticity in spatial navigation by recording the activity of hippocampal place cells in transgenic L7PKCI mice with selective disruption of PKC-dependent plasticity at parallel fiber-Purkinje cell synapses. Place cell properties were exclusively impaired when L7PKCI mice had to rely on self-motion cues. The behavioral consequence of such a deficit is evidenced here by selectively impaired navigation capabilities during a path integration task. Together, these results suggest that cerebellar PKC-dependent mechanisms are involved in processing self-motion signals essential to the shaping of hippocampal spatial representation. |
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