Sodium- and potassium-activated adenosine triphosphatase of gills: role in adaptation of teleosts to salt water

The activity of adenosine triphosphatase activated by sodium and potassium ions is greatly increased in the gill and pseudobranch of the euryhaline killifish, Fundulus heteroclitus, after its adaptation to seawater. Adenosine triphosphatase activity in gills of fish in salt water is reduced by hypophysectomy. The data suggest that this enzyme is involved in the excretion of sodiumions by the gill and that the adaptive increase which occurs in seawater is influenced by the hypophysis.