Perioperative desmopressin prolongs survival in surgically treated bitches with mammary gland tumours: a pilot study |
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Authors: | Hermo Guillermo A Torres Perla Ripoll Giselle V Scursoni Alejandra M Gomez Daniel E Alonso Daniel F Gobello Cristina |
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Affiliation: | Laboratory of Molecular Oncology, Department of Science and Technology, Quilmes National University, Argentina. ghermo@unq.edu.ar |
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Abstract: | Desmopressin (1-deamino-8-d-arginine vasopressin, also known as DDAVP) is a safe haemostatic compound capable of inhibiting lymph node and lung metastasis in a mouse model of mammary tumour manipulation and surgical excision. The aim of this study was to test the efficacy and safety of perioperative DDAVP (1microg/kg) in surgically treated bitches with mammary gland tumours (MGT). Twenty-one, otherwise healthy, intact bitches, with malignant MGT stage III or IV were randomly allocated to DDAVP (n=11) or placebo (n=10) groups. En bloc mastectomy of the affected gland/s was performed. DDAVP had a significant beneficial effect on disease-free period (P<0.01) and overall survival time (P<0.05). No side effects were seen in any of the cases. Whatever the mechanism of action, it seems that DDAVP may have a novel use in cancer surgery to minimise spread or survival of residual malignant cells. Additional, large scale controlled trials are required to fully evaluate this adjuvant pharmacological protocol. |
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