EVALUATING THE CLINICAL AND PHYSIOLOGICAL EFFECTS OF LONG-TERM ULTRAVIOLET B RADIATION ON RABBITS (ORYCTOLAGUS CUNICULUS) |
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| Institution: | 1. Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL, USA;2. Department of Pathobiology, University of Illinois, Urbana, IL, USA;3. Oxbow Animal Health, Omaha, NE, USA;4. PetSmart, Phoenix, AZ, USA.;1. FauneVET, Nantes, France;2. Clinique Vétérinaire des Rochettes, Montaigu, France;3. Centre Hospitalier Vétérinaire Atlantia, Nantes, France;1. Department of Clinical Medicine and Surgery, University of Veterinary and Animal Sciences, Lahore, Pakistan;2. Department of Epidemiology and Public Health, University of Veterinary and Animal Sciences, Lahore, Pakistan;3. Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan;4. Department of Clinical Medicine and Surgery, University of Agriculture, Faisalabad, Pakistan;5. Department of Population Medicine and Diagnostic Sciences Cornell University College of Veterinary Medicine Ithaca, New York, USA;6. College of Animal Science and Technology, Yunnan Agriculture University, Kunming, 650201, Yunnan, China.;1. Department of Clinical Sciences, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran;2. Ophthalmology Section, Negah Veterinary Centre, Tehran, Iran;3. Bu Ali Sina University, Hamadan, Iran;4. Department of Internal medicine, Veterinary Medicine Faculty, University of Tehran, Tehran, Iran;5. Department of Veterinary Medicine, Madingley Road, Cambridge, United Kingdom CB3 0ES.;1. National Autonomous University of Mexico, Mexico City, CDMX, Mexico;2. National Autonomous University of Mexico Mexico City, CDMX, Mexico |
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| Abstract: | Vitamin D is an essential hormone in vertebrates. Most animals acquire this hormone through their diet and/or exposure to ultraviolet B (UVB) radiation. The objectives for this research were to evaluate the clinical and physiologic effects of artificial UVB light supplementation on rabbits (Oryctolagus cuniculus) and to evaluate the long-term safety of artificial UVB light supplementation over a 6-month period. Twelve New Zealand white rabbits were randomly assigned to one of two treatment groups: Group A was exposed to 12 hours of artificial UVB radiation daily and Group B received ambient fluorescent light with no UVB supplementation for 12 hours daily. All animals were offered the same diet and housed under the same conditions. Blood samples were collected every 3 weeks over 6 months to measure blood chemistry values, parathyroid hormone, ionized calcium, and serum 25-hydroxyvitamin D3 (25-OHD3) levels. Serial ophthalmologic examinations were performed at the beginning of the study and every 2 months thereafter. At the end of the study the animals were euthanized and necropsied. Mean ± SD serum 25-OHD3 concentrations differed significantly (P = 0.003) between animals provided supplemental UVB radiation (83.12 ± 22.44 nmol/L) and those not provided UVB radiation (39.33 ± 26.07 nmol/L). There were no apparent negative clinical or pathologic side effects noted between the groups. This study found that exposing rabbits to UVB radiation long term significantly increased their circulating serum 25-OHD3 levels, which was sustainable over time. |
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