阿托伐他汀和辛伐他汀对降脂及消退颈动脉斑块疗效的对比研究

目的:比较阿托伐他汀和辛伐他汀消退老年人颈动脉粥样斑块及降脂疗效。方法:选择存在颈动脉粥样斑块的143例高脂血症的老年患者,随机分为阿托伐他汀组(n=72)及辛伐他汀组(n=71)。阿托伐他汀组每晚服阿托伐他汀10 m g,辛伐他汀组每晚服辛伐他汀20 m g,均连续服药12周。观察其对血脂各项指标(TC、TG、LDL-C、HDL-C)及肝肾功能的影响,并进行颈动脉多普勒超声检查。结果:两药均能降低TC、TG和升高HVD-C,治疗前后比较差异有显著性(P<0.01);同时两药对老年人颈动脉粥样斑块均有一定的消退作用,但阿托伐他汀优于辛伐他汀。结论:阿托伐他汀能明显降低血脂,能消退颈动脉粥样斑块,且阿托伐他汀的降脂和消退斑块疗效优于辛伐他汀。

Comparison of atorvastatin and simvastatin in hypolipemic effect and atheromatous plaque resolution of carotid artery in senile patients with hyperlipemia

Objective: To compare the effects of atorvastatin versus simvastatin on lipid-lowering and atheromatous plaque resolution of carotid artery in senile patients with hyperlipemia. Methods: A total of 143 gerontal patients with hyperlipemia and carotid atheromatous plaques were randomly divided into atorvastatin group(n=72) and simvastatin group(n=71),and both groups received atorvastatin(10mg/d) and simvastatin(20mg/d) for 12 weeks,respectively.The blood lipid,liver and renal function,and the carotid plaques before and after the treatment were determined by biochemical analyzer and Doppler ultrasonography,respectively.Results: TC and TG levels decreased,and HDL-C contents increased significantly after atorvastatin or simvastatin treatment(P<0.01).The atheromatous plaques of carotid artery in both groups showed obvious resolution,especially in atorvastatin group.Conclusion: The lipid-lowering efficacy and carotid plaque resolution of atorvastatin are superior to those of simvastain in elderly patients with hyperlipemia.