Further studies on the antinociceptive activity and respiratory effects of buprenorphine in sheep |
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Authors: | A E WATERMAN A LIVINGSTON A AMIN |
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Institution: | Department of Veterinary Surgery, University of Bristol, UK. |
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Abstract: | The thermal and mechanical analgesic profile of buprenorphine at a dose rate of 1.5 micrograms/kg i.v. was investigated in five sheep. This dose produced significant analgesia for 40 min against the thermal stimulus, but no mechanical antinociception. A higher dose rate of 12 micrograms/kg also failed to produce antinociception to a mechanical stimulus. In addition, the effect of the drug (6 micrograms/kg) on respiratory gas tensions was determined and no significant changes were observed. |
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