Antinephritis and radical scavenging activity of prenylflavonoids |
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Authors: | Fukai Toshio Satoh Kazue Nomura Taro Sakagami Hiroshi |
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Institution: | School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. fukai@phar.toho-u.ac.jp |
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Abstract: | Antinephritis activity of 5 prenylflavonoids similar to glabridin (1-5), isolated from Morus alba, Artocarpus communis, Glycyrrhiza uralensis and G. inflata, was evaluated in mice with glomerular disease (Masugi-nephritis). Oral administrations of artonin E (2) or licochalcone A (4) for 10 days (30 mg kg(-1) day(-1)) reduced the amount of urinary protein excretion compared to nephritic mice. ESR spectroscopy demonstrated that morusin (1) and licorisoflavan A (5) increased the radical intensity of sodium ascorbate by about two times. Morusin, licoricidin (3), licochalcone A and licorisoflavan A showed weak scavenging activity against superoxide anion radical. |
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Keywords: | Morus alba Artocarpus communis Glycyrrhiza uralensis Glycyrrhiza inflata Prenylflavonoids Antinephritis Superoxide anion radical |
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