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Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein
Authors:T C Theoharides  W Sieghart  P Greengard  W W Douglas
Abstract:Cromolyn inhibited histamine release from mast cells that was induced by a classic secretagogue and correspondingly increased incorporation of radioactive phosphate into a 78,000-dalton protein. These effects on histamine secretion and on protein phosphorylation were rapid in onset and both showed tachyphylaxis. Cromolyn may therefore act by altering the phosphorylation of a protein involved in the regulation of secretion.
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